13288-48-7

Basic information

• Product Name: 1-[2-(dimethylamino)phenyl]cyclohexanol
• CAS NO: 13288-48-7
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.3226
• Mol File: 13288-48-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 350°C at 760 mmHg
• Flash Point: 165°C
• Density: 1.074g/cm³
• Vapor Pressure: 1.69E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 1-[2-(dimethylamino)phenyl]cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(dimethylamino)phenyl]cyclohexanol(13288-48-7)
• EPA Substance Registry System: 1-[2-(dimethylamino)phenyl]cyclohexanol(13288-48-7)

Safety Data

• Hazardous Substances Data: 13288-48-7(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Structure

Cyclohexanol derivative with a dimethylamino phenyl group attached to the cyclohexane ring

Chirality

Chiral compound, existing as a pair of enantiomers

Applications

a. Precursor in the synthesis of pharmaceuticals and other organic compounds
b. Chiral resolving agent in chromatography
c. Reagent in organic synthesis
d. Potential use as a central acting muscle relaxant
e. Investigated for its possible use as a local anesthetic

Upstream product

• 108-94-1 cyclohexanone 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 10483-02-0 2-cyclohex-1-enyl-N,N-dimethyl-aniline 

Relevant articles and documents

Bidentate N, O-aluminum complexes: Synthesis, characterization and catalytic study for MPV reduction reactions

Treatment of AlMe3 with bidentate N, O-ligands, HOC(Me)(Ph)C6H4-NMe2-2 (L1H) or HOC(CH2)5C6H4-NMe2-2 (L2H) in different molar ratios, four novel aluminum complexes [Me2AlOC(Me)(C6H5) C6H4-NMe2-2] (1), [Me2AlOC(Me)(CH2) C6H4-NMe2-2] (2), [Me2Al{OC(Me)(C6H5) C6H4-NMe2-2}2] (3) and[Me2Al{OC(Me)(CH2)5 C6H4-NMe2-2}2] (4) were obtained in good yield. Complexes 1-4 were characterized by 1H and 13C NMR spectroscopy, elemental analyses and single crystal X-ray diffraction techniques. Each of the complexes 1, 2, 3 and 4 was tested for the capable of catalyzed Meerwein-Ponndorf-Verley (MPV) reduction of ketones or aldehydes with low catalyst loadings under mild conditions and showed good to excellent catalytic activities.