1328880-40-5Relevant articles and documents
K2CO3-mediated synthesis of functionalised 4-substituted-2-amino-3-cyano-4H-chromenes via michael-cyclization reactions
He, Yanyang,Hu, Rong,Li, Fengqiong,Zhang, Mei,Tong, Rongsheng,Shi, Jianyou
, p. 19253 - 19268 (2014)
An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K2CO3 catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.