1328886-23-2Relevant academic research and scientific papers
Formal synthesis of the bryostatin Northern Hemisphere: Asymmetric synthesis of the B ring and C1-C9 fragment
Nakagawa-Goto, Kyoko,Crimmins, Michael T.
, p. 1413 - 1418 (2011/08/03)
A formal synthesis of the top half fragment of bryostatin 11 has been developed. Stereoselective construction of the B ring was achieved by using a ring-closing metathesis reaction in conjunction with asymmetric glycolate alkylation. Furthermore, the C1-C9 fragment was synthesized by Brown allylation, chelation-controlled aldol condensation, and Saksena-Evans reduction to construct all stereogenic centers. Georg Thieme Verlag Stuttgart - New York.
