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Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1H-pyrazole-3-carboxylic acid is used as a key intermediate for the synthesis of novel inhibitors of Rho/MRTF/SRF transcription. These inhibitors have potential antifibrotic properties, making them valuable in the development of treatments for scleroderma, a chronic autoimmune disease characterized by the thickening and hardening of the skin and connective tissues.

Upstream product

• 5744-68-3 5-bromo-3-methyl-1H-pyrazole 

Relevant academic research and scientific papers

Method for synthesizing chlorantraniliprole

A solvent containing 2 - amino -3 - methylbenzoic acid is stirred, N - methyl -3 - methyl -2 - amino - benzamide is dissolved in alkali liquor in a stirring reaction process, and reacted with NCS to obtain N - methyl -3 - methyl -2 - amino -5 - chloro - benzamide. The reaction of the bromination reaction, the oxidation reaction and the condensation reaction is carried out by cooperation of a catalyst so as to obtain chlorantraniliprole. By optimizing the preparation steps of chlorantraniliprole, the whole process is relatively simple in process steps, the post-treatment is simple, intermediate products can be obtained directly after the single step is finished, high environmental control requirements are not needed in the whole synthesis step, and industrialization can be conveniently realized.