132894-38-3

Upstream product

• 75143-76-9 5-(3-chlorostyryl)-3-methyl-4-nitroisoxazole 
• 105-53-3 diethyl malonate 
• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 132894-40-7 3-(3-chlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)butanoic acid 
• 132869-29-5 5,6,7,8-tetrahydro-7-(3-chlorophenyl)-3-methyisoxazolo<4,5-b>azepin-5(4H)-one 
• 934351-67-4 3-(3-chloro-phenyl)-4-(5-methyl-4-nitro-2H-pyrazol-3-yl)-butyric acid 

Relevant academic research and scientific papers

Modular syntheses of isoxazoloazepinones and pyrazoloazepinones

Herein we described an optimised synthesis of isoxazoloazepinone and novel heterocycle pyrazoloazepinone. These syntheses are modular in nature and fast to execute. The title compounds were obtained pure without the intervention of chromatography.

PREPARATION OF 5,6,7,8-TETRAHYDRO-7-ARYL-3-METHYLISOXAZOLOAZEPIN-5(4H)-ONES

3-Methyl-4-nitro-5-styrylisoxazoles (1a-e) reacted with diethyl malonate to give the corresponding Michael adducts (2a-e) which have been hydrolyzed to 4-(3-methyl-4-nitroisoxazol-5-yl)-3-phenyl(chlorophenyl)butanoic acids (3a-e).Subsequent reduction of t