132901-86-1Relevant academic research and scientific papers
Controlled chemical release of hydrogen sulfide
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Page/Page column 14; 15; 16, (2015/09/22)
Agents of formula: where R1 and R2 vary independently and are acyl, sulfonyl, phosphoryl, alkyl, substituted alkyl, halogen, aryl, arylalkyl, substituted aryl, heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, heterocycle, or heteroatoms; and R3 is H or a member of a ring structure which includes R2, are provided; as are agents of formula: where R1, R2 and R3 vary independently and: R1=OH, OR′, NHR′, NR′R″ (with R′ R″=alkyl, aryl, heteroaryl, etc); R2=acyl, alkyl, aryl, sulfonyl, etc; R3=alkyl, aryl, substituted aryl, heteroaryl, etc; and R4 and R5 are (independently) H, methyl or alkyl, substituted alkyl, aryl, substituted aryl, etc. Methods of using the agents to treat e.g. cardiovascular disease, stroke, shock, injuries caused by hypoxia, male erectile dysfunction, and Alzheimer's are provided.
Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors
Zhao, Yu,Yang, Chuntao,Organ, Chelsea,Li, Zhen,Bhushan, Shashi,Otsuka, Hiro,Pacheco, Armando,Kang, Jianming,Aguilar, Hector C.,Lefer, David J.,Xian, Ming
supporting information, p. 7501 - 7511 (2015/10/05)
Hydrogen sulfide (H2S) is a signaling molecule which plays regulatory roles in many physiological and/or pathological processes. Therefore, regulation of H2S levels could have great potential therapeutic value. In this work, we report the design, synthesis, and evaluation of a class of N-mercapto (N-SH)-based H2S donors. Thirty-three donors were synthesized and tested. Our results indicated that controllable H2S release from these donors could be achieved upon structural modifications. Selected donors (NSHD-1, NSHD-2, and NSHD-6) were tested in cellular models of oxidative damage and showed significant cytoprotective effects. Moreover, NSHD-1 and NSHD-2 were also found to exhibit potent protective effects in a murine model of myocardial ischemia reperfusion (MI/R) injury.
Cysteine-activated hydrogen sulfide (H2S) donors
Zhao, Yu,Wang, Hua,Xian, Ming
supporting information; experimental part, p. 15 - 17 (2011/03/17)
H2S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H2S has been hindered by the lack of controllable H2S donors that could mimic the slow and continuous H2S generation process in vivo. Herein we report a series of cysteine-activated H2S donors. Structural modifications of these molecules can regulate the rates of H2S generation. These compounds can be useful tools in H2S research.
The first oxathiazolium cations - A simple synthesis of 1,3,4-oxathiazolium salts
Yung, Tommy W. K.,Sammes, Michael P.
, p. 5935 - 5938 (2007/10/02)
The 1,3,4-oxathiazolium salts (11,12), which are the first representatives of the six possible classes of aromatic oxathiazolium cations, are readily prepared by N-acylation of the S-acylthiohydroxylamines ( 7,8) followed by cyclization with a strong acid and an acyl anhydride. The positive charge appears to be delocalized to a smaller extent than in analogous dithiazolium salts.
