132902-37-5Relevant academic research and scientific papers
Asymmetric Cyanosilylation of Ketones Catalyzed by Bifunctional Chiral N-Oxide Titanium Complex Catalysts
Shen, Yongcun,Feng, Xiaoming,Li, Yan,Zhang, Guolin,Jiang, Yaozhong
, p. 129 - 137 (2007/10/03)
A new bifunctional catalytic system based on chiral N-oxide titanium complexes has been used for the asymmetric cyanosilylation of ketones. Screening of a variety of chiral N-oxide metal complexes resulted in (1R,2S)-1-(2'-pyridylmethyl)-2-(diphenylhydroxymethyl)pyrrolidine N-oxide titanium complex, which gave O-TMS cyanohydrins in good yields with enantiometric excesses of up to 69 percent. A catalytic cycle based on experimental phenomena and studies was proposed to explain the origin of the asymmetric induction.
CHIRAL LIGANDS CONTAINING HETEROATOMS. 6. 1-(2-PYRIDYLMETHYL)PYRROLIDINE IN THE CHIRAL CATALYSIS OF ADDITION OF DIETHYLZINC TO BENZALDEHYDE
Chelucci, Giorgio,Falorni, Massimo,Giacomelli, Giampaolo
, p. 843 - 849 (2007/10/02)
The synthesis of a series of new optically active pyridine ligands from proline derivatives has been developed for the enantioselective addition of dialkyl zinc compounds to aldehydes.The results obtained indicate that the corrdination of a metal atom to the nitrogen of the pyridine ring is essential in determining the stereochemistry of the process.
