132912-33-5Relevant academic research and scientific papers
Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge
Kotoku, Naoyuki,Fujioka, Shinichi,Nakata, Chiaki,Yamada, Masaki,Sumii, Yuji,Kawachi, Takashi,Arai, Masayoshi,Kobayashi, Motomasa
, p. 6673 - 6678 (2011/09/30)
Structure-activity relationship of furospinosulin-1 (1), a hypoxia-selective growth inhibitor isolated from marine sponge, was investigated. Concise synthetic method of 1 was developed, and some structurally modified analogues were prepared. Biological evaluation of them revealed that the whole chemical structure was important for the hypoxia-selective growth inhibitory activity of 1. Among prepared, the desmethyl analogue 30 showed excellent hypoxia-selective inhibitory activity similar to that of 1 and also exhibited in vivo anti-tumor activity with oral administration.
Total Synthesis of Dehydroambliol-A and Its Unnatural Z Isomer
Magatti, Charles V.,Kaminski, James J.,Rothberg, Irvin
, p. 3102 - 3108 (2007/10/02)
Convergent total syntheses of dehydroambliol-A (1a), its unnatural Z isomer 1b, and ambliofuran (2) are described.The syntheses utilized 2-(3'-furyl)-1,3-dithiane (6) as a common intermediate.Analysis of their proton and carbon magnetic resonance spectra confirm that in the natural product dehydroambliol-A and in synthetic dehydroambliol-A the Δ7-bond possesses the E geometry, while in the unnatural isomer of dehydroambliol-A, the Δ7-bond is of the Z configuration.
