132924-48-2Relevant academic research and scientific papers
Development of a scaleable synthesis of a geminal dimethyl tertiary amine as an inhaled muscarinic antagonist for the treatment of COPD
Dillon, Barry R.,Roberts, Dannielle F.,Entwistle, David A.,Glossop, Paul A.,Knight, Craig J.,Laity, Daniel A.,James, Kim,Praquin, Celine F.,Strang, Ross S.,Watson, Christine A. L.
, p. 195 - 203 (2012)
An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C-H amination step. The final route includes a reproducible modified Bouveault reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology.
HYDROCHLORIDE SALT OF 5-R3-F3-TIVDROXYPHENOXY)AZETIDIπ-1-Vπ-5-METHYL-2.2- DIPHENYLHEXANAMIDE
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Page/Page column 17, (2009/01/20)
This invention relates to the hydrochloride salt of 5-[3-{3-hydroxyphenoxy)azetidin-1-yl]-5- methyl-2,2-diphenylhexanamide or derived form thereof and its use as a medicament.
