931409-24-4

Upstream product

• 6523-63-3 4-cyano-4,4-diphenylbutanoic acid 
• 123-51-3 i-Amyl alcohol 
• 1079781-24-0 5-[3-(3-methoxyphenoxy)azetidin-1-yl]-5-oxo-2,2-diphenylpentanenitrile 
• 132924-48-2 1-benzhydryl-3-(3-methoxyphenoxy)azetidine 
• 1374308-52-7 5-methyl-2,2-diphenyl-5-(3-{3-(propenyl)oxyphenoxy}azetidin-1-yl)hexanamide 
• 1355533-05-9 5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile 
• 931409-69-7 tert-butyl 4-cyano-4,4-diphenylbutanoate 
• 813440-67-4 4,4-dimethyl-[1,2,3]oxathiazinane 2,2-dioxide 
• 86-29-3 Diphenylacetonitrile 
• 931410-10-5 methanesulfonic acid 1-(4-cyano-1,1-dimethyl-4,4-diphenylbutyl)azetidi-3-yl ester 
• 1355532-89-6 5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride 
• 521267-13-0 tert-butyl 4,4-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide 
• 931409-66-4 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile 

Downstream Products

• 1079781-31-9 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2 diphenyl hexanamide hydrochloride 

Relevant academic research and scientific papers

Development of a scaleable synthesis of a geminal dimethyl tertiary amine as an inhaled muscarinic antagonist for the treatment of COPD

An efficient and scalable process for the synthesis of muscarinic antagonist, PF-3635659 1, is described, illustrating redesign of an analogue-targeted synthesis which contained a scale-limiting rhodium-activated C-H amination step. The final route includes a reproducible modified Bouveault reaction which has not previously been reported on a substrate of this complexity, or on such a scale with over 5 kg of the requisite gem-dimethylamine prepared via this methodology.

Inhalation by design: Novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease

A novel tertiary amine series of potent muscarinic M3 receptor antagonists are described that exhibit potential as inhaled long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease. Geminal dimethyl functionality pr

HYDROCHLORIDE SALT OF 5-R3-F3-TIVDROXYPHENOXY)AZETIDIπ-1-Vπ-5-METHYL-2.2- DIPHENYLHEXANAMIDE

This invention relates to the hydrochloride salt of 5-[3-{3-hydroxyphenoxy)azetidin-1-yl]-5- methyl-2,2-diphenylhexanamide or derived form thereof and its use as a medicament.

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.