132928-39-3Relevant academic research and scientific papers
Organocatalytic valorisation of glycerol: Via a dual NHC-catalysed telescoped reaction
Axelsson,Antoine-Michard,Sundén
, p. 2477 - 2481 (2017)
A general telescoped reaction for the NHC-catalysed carbonation and aerobic esterification of glycerol and 2-amino-2-methylpropane-1,3-diol has been developed. The reaction provides highly functionalised glycerol derivatives in good to excellent yields (up to 95%) using low catalyst loadings and ambient conditions.
Ultrasonic-promoted enzymatic preparation, identification and multi-active studies of nature-identical phenolic acid glycerol derivatives
Dong, Zhe,Liu, Zengshe,Sun, Teng,Zhang, Haiping,Zheng, Mingming
, p. 11139 - 11147 (2020/04/03)
Phenolic acid glycerols (PAGs) are a group of rare phytochemicals found from potato periderm, which show great potential in the food, cosmetic and pharmaceutical industries. In this study, seven PAGs were enzymatically synthesized via transesterification of ethyl phenates (EPs) with glycerol by ultrasonic promotion. The conversions of 88.1-98.5% could be obtained in 1-9 h. Compared with the conventional stirring methods, the catalytic efficiency was significantly increased 11.0-44.0 folds by ultrasound assistance. The lipid peroxidation inhibition activity increased 8.1-fold and 14.4-fold compared to the parent phenolic acids (PAs). Furthermore, caffeoyl glycerol and feruloyl glycerol exhibited excellent antimicrobial activity against Escherichia coli compared to the corresponding PAs with minimum inhibitory concentration (MIC) decreasing 4-16-fold. The PAGs can also absorb a much wider and higher amount of the harmful UV-B rays than the corresponding PAs. The present strategy for facile synthesis of multifunctional PAGs paves the way for the development and application of natural phytochemicals and novel ingredients.
Synthesis of Some Phenylpropanoid Monoglycerides via the Mitsunobu Protocol
Batovska, Daniela I.,Kishimoto, Takao,Bankova, Vassya S.,Kamenarska, Zornitsa G.,Ubukata, Makoto
, p. 552 - 558 (2020/05/13)
Natural monoglycerides of cinnamic, ferulic and p-coumaric acids were synthesized in good to high overall yields from isopropylidene glycerol via the Mitsunobu reaction and further deprotection of the corresponding acetonides with Amberlyst 15. The method avoids the need of protection of the phenolic hydroxyls. During the Mitsunobu esterifications a strong influence of the acid strength on the efficacy and outcome of the reaction was observed.
