132975-07-6

Basic information

• Product Name: S-(2-Mercaptoethyl) thiobenzoate
• Synonyms: S-(2-Mercaptoethyl) thiobenzoate
• CAS NO: 132975-07-6
• Molecular Weight: 198.31
• Mol File: 132975-07-6.mol

Chemical Properties

• CAS DataBase Reference: S-(2-Mercaptoethyl) thiobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(2-Mercaptoethyl) thiobenzoate(132975-07-6)
• EPA Substance Registry System: S-(2-Mercaptoethyl) thiobenzoate(132975-07-6)

Safety Data

• Hazardous Substances Data: 132975-07-6(Hazardous Substances Data)

Upstream product

• 132975-05-4 2-Methoxy-2-phenyl-1,3-dithiolane 
• 132975-06-5 2-Ethoxy-2-phenyl-1,3-dithiolane 
• 98-88-4 benzoyl chloride 
• 540-63-6 ethane-1,2-dithiol 

Downstream Products

• 51290-80-3 S,S'-ethane-1,2-diyl dibenzothioate 
• 1374755-68-6 C₄₉H₆₀N₃O₉PS₂Si 
• 1374755-67-5 C₅₂H₆₃N₆O₉PS₂Si 
• 1374755-66-4 C₅₁H₆₃N₄O₉PS₂Si 
• 1374755-65-3 C₅₇H₆₅N₆O₈PS₂Si 
• 135472-48-9 C₂₅H₃₂O₂S₄ 

Relevant articles and documents

Synthesis of phosphorodithioate DNA via sulfur-linked, base-labile protecting groups

Phosphorodithioate DNA, a new and potentially useful DNA analog with a deoxynucleoside-OPS2O-deoxynucleoside internucleotide linkage, was synthesized from deoxynucleoside 3'-phosphorothioamidites having a variety of thioesters and thiocarbonates as base-labile phosphorus protecting groups. The major challenge in the synthesis of this DNA analog was to derive a reaction pathway whereby activation of deoxynucleoside 3'-phosphorothioamidites occurred rapidly and in high yield under conditions that minimize Arbuzov rearrangements, exchange reactions, unwanted oxidation to phosphorothioates, and several other side reactions. Of the various phosphorus protecting groups examined for this purpose, a thorough evaluation of these parameters led to the conclusion that β-(benzoylmercapto)ethyl was preferred. Synthesis of phosphorodithioate DNA began by preparing deoxynucleoside 3'-phosphorothioamidites from the appropriately protected deoxynucleoside, tris(pyrrolidino)phosphine, and ethanedithiol monobenzoate via a one-flask synthesis procedure. These synthons were activated with tetrazole and condensed with a deoxynucleoside on a polymer support to yield the deoxynucleoside thiophosphite. Subsequent steps involved oxidation with sulfur to generate the completely protected phosphorodithioate triester, acylation of unreacted deoxynucleoside, and removal of the 5'-protecting group. Yields per cycle were usually 97-98% with 2-5% phosphorothioate contamination as determined by 31P NMR. By using deoxynucleoside 3'-phosphorothioamidites and deoxynucleoside 3'-phosphoroamidites, deoxyoligonucleotides having phosphorodithioate and the natural phosphate internucleotide linkages in any predetermined order can also be synthesized.

Synthesis of dithioetherdithiols, potential technetium complexing agents

The following dithioetherdithiols : 2,10-dimethyl-4,8-dithiaundecane-2,10-dithiol 1, 5-butyl-3,7-dithianonane-1,9-dithiol 2 and 4,4,6,6-tetramethyl-3,7-dithianonane-1,9-dithiol 3 have been synthesized.These compounds are very attractive as potential precu

Photosolvolysis of 2-Alkoxy-2-phenyl-1,3-dithiolane

2-Methoxy- and 2-ethoxy-2-phenyl-1,3-dithiolane are hydrolyzed to the thioester in neutral aqueous solution by irradiation with a low-pressure Hg lamp. Irradiation of a solution of the alkoxy dithiolanes in alcohol induces easily the alcohol exchange.