132979-94-3Relevant academic research and scientific papers
Straightforward Synthesis of 1,2,3-Tricarbonyl Systems
Linde, Robert G.,Jeroncic, Lucio O.,Danishefsky, Samuel J.
, p. 2534 - 2538 (1991)
A simple two-step protocol for the preparation of α,β-diketo amides is described.The first step involves condensation of the anion of an α-phenylthio amide with an aldehyde.This is followed by oxidation of the resulting β-hydroxy α-sulfide with the Dess-Martin periodinane.The vicinal tricarbonyl system is obtained in good to excellent yields.
