Straightforward Synthesis of 1,2,3-Tricarbonyl Systems

Article abstract of DOI:10.1021/jo00007a049

A simple two-step protocol for the preparation of α,β-diketo amides is described.The first step involves condensation of the anion of an α-phenylthio amide with an aldehyde.This is followed by oxidation of the resulting β-hydroxy α-sulfide with the Dess-Martin periodinane.The vicinal tricarbonyl system is obtained in good to excellent yields.