132980-99-5

Basic information

• Product Name: 3,5-DIFLUOROBENZAMIDE
• Synonyms: 3,5-DIFLUOROBENZAMIDE;Difluorobenzamide6;Benzamide, 3,5-difluoro- (9CI);3,5-Difluorobenzamide 97%;3,5-Difluorobenzamide97%
• CAS NO: 132980-99-5
• Molecular Formula: C₇H₅F₂NO
• Molecular Weight: 157.12
• EINECS: -0
• Product Categories: HALIDE;AMIDE;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 132980-99-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 155-159 °C(lit.)
• Boiling Point: 51-52C
• Flash Point: 67.3 °C
• Appearance: /
• Density: 1,199g/cm
• Vapor Pressure: 0.622mmHg at 25°C
• Refractive Index: 1,507-1,509
• Storage Temp.: Store below +30°C.
• BRN: 4177620
• CAS DataBase Reference: 3,5-DIFLUOROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIFLUOROBENZAMIDE(132980-99-5)
• EPA Substance Registry System: 3,5-DIFLUOROBENZAMIDE(132980-99-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 132980-99-5(Hazardous Substances Data)

Usage

General Description

3,5-Difluorobenzamide is a chemical compound with the molecular formula C7H5F2NO. It is a white solid that is used in the production of pharmaceuticals and agrochemicals. 3,5-Difluorobenzamide is a derivative of benzamide, with two fluorine atoms attached to the 3 and 5 positions of the benzene ring. 3,5-DIFLUOROBENZAMIDE is known for its ability to act as an inhibitor of the enzyme N-Myristoyltransferase, which has potential applications in the treatment of cancer and other diseases. It is important to handle 3,5-Difluorobenzamide with care, as it can be harmful if it comes into contact with the skin, eyes, or respiratory system. Overall, this compound has important industrial applications and potential as a therapeutic agent.

InChI:InChI=1/C7H5F2NO/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,(H2,10,11)

Upstream product

• 32085-88-4 3,5-difluorobenzaldehyde 
• 455-40-3 3,5-difluorobenzoic acid 
• 129714-97-2 3,5-difluorobenzoyl chloride 
• 64248-63-1 3,5-difluorobenzonitrile 

Downstream Products

• 403509-27-3 N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3,5-difluorobenzamide 
• 1253388-74-7 C₃₅H₂₁F₂NO 
• 1449485-70-4 3,5-difluoro-2-(3-methoxybenzyl)benzamide 
• 1449485-78-2 2-(2-bromobenzyl)-3,5-difluorobenzamide 
• 1449485-83-9 2-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-3,5-difluorobenzamide 
• 670397-79-2 2-(3,5-difluorophenyl)benzo[d]oxazole 
• 1415749-95-9 C₇H₄Cl₂F₂NO₂P 

Relevant articles and documents

GOLD COMPLEXES

Gold (I) hydroxide complexes of the form Z-Au-OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.

[{Au(IPr)}2(μ-OH)]X complexes: Synthetic, structural and catalytic studies

The synthesis of a series of dinuclear gold hydroxide complexes has been achieved. These complexes of type [{Au(IPr)}2(Iμ-OH)]X (X=BF 4, NTf2, OTf, FABA, SbF6; IPr=2,6- bis(disopropylphenyl)imidazol-2-ylidene; NTf2= bis(trifluoromethanesulfonyl)imidate; OTf=trifluoromethanesulfonate; FABA=tetrakis(pentafluorophenyl)borate) are easily formed in the presence of water and prove highly efficient in the catalytic hydration of nitriles. Their facile formation in aqueous media suggests they are of relevance in gold-catalyzed reactions involving water. Additionally, a series of [Au(IPr)(NCR)][BF4] (R=alkyl, aryl) complexes was synthesized as they possibly occur as intermediates in the catalytic reaction mechanism. 1H and 13C NMR data as well as key bond lengths obtained by X-ray diffraction studies are compared and reveal an interesting structure-activity relationship. The collected data indicate a negligible effect of the nature of the nitrile on the reactivity of [Au(L)(NCR)][X] complexes in catalysis.

Prodrugs of neuron-selective monoamine oxidase inhibitors: Amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes

Six amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes and their parent amines were synthezised and tested for their potency and selectivity in inhibiting monoamine oxidase (MAO) in vitro and in vivo. The amino acid derivatives were 300-1000 times less potent than the parent amines in inhibiting the MAO-A activity in a rat brain mitochondrial preparation in vitro. All compounds, except the (R)-valinamide derivative (22), were potent inhibitors of MAO in the rat brain in vivo and were, like the parent amines markedly more potent within the monoaminergic neurons than in other neurons. The glycinamide derivative 7 showed the largest difference between intra- and extra-neuronal inhibition in serotonergic neurons. The time course of the inhibitory effect of 7 in vivo showed that it is a reversible inhibitor with a long duration.