32085-88-4

Basic information

• Product Name: 3,5-Difluorobenzaldehyde
• Synonyms: 3,5-DIFLUOROBENZALDEHYDE;3,5-Difluorobenzaldehyde,97%;3,5-Difluorobenzaldehyde, 98+%;3,5-Difluorobenzaldehyde 98%;3,5-Difluorobenzalde;1,2-DiFluorobenzenebenzaldehyde;1,3-Difluoro-5-formylbenzene;3,5-fluorobenzaldehyde
• CAS NO: 32085-88-4
• Molecular Formula: C₇H₄F₂O
• Molecular Weight: 142.1
• EINECS: -0
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Miscellaneous;Fluorobenzaldehyde Series;Aldehydes;C7;Carbonyl Compounds;Fluorine series
• Mol File: 32085-88-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 17°C
• Boiling Point: 61-63°C 43mm
• Flash Point: 133 °F
• Appearance: Clear light green/Liquid After Melting
• Density: 1.296 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.292mmHg at 25°C
• Refractive Index: n20/D 1.493(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• BRN: 2573392
• CAS DataBase Reference: 3,5-Difluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluorobenzaldehyde(32085-88-4)
• EPA Substance Registry System: 3,5-Difluorobenzaldehyde(32085-88-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 1989 3/PG 3
• WGK Germany: 3
• F: 10-21
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 32085-88-4(Hazardous Substances Data)

Usage

Chemical Properties

clearlightgreenliqui

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

General Description

The 19F{′H} spectra of 3,5-difluorobenzaldehyde at low temperature in dimethyl ether solution was studied.

InChI:InChI=1/C8H3F6NO2/c9-7(10,11)4-1-2-5(8(12,13)14)6(3-4)15(16)17/h1-3H

Upstream product

• 127598-81-6 N-(3,5-difluorobenzyl) N-(2-cyanoethyl)-4-methylaniline 
• 62351-47-7 3,5-difluorophenylmagnesium bromide 
• 93-61-8 N-methyl-N-phenylformamide 
• 119072-55-8 tert-butylisonitrile 
• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 117358-51-7 1,3-difluoro-5-methylbenzene 
• 461-96-1 3,5-difluorobromobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 64248-63-1 3,5-difluorobenzonitrile 
• 127598-68-9 N-(3,5-difluorobenzyl)-4-methylaniline 
• 127598-61-2 N-(3,5-difluorobenzylidene)-4-methylaniline 
• 101471-20-9 2-bromo-4,6-difluoroaniline hydrobromide 
• 367-25-9 2,4-difluorophenylamine 
• 79538-20-8 3,5-difluorobenzyl alcohol 

Downstream Products

• 84315-23-1 (trans)-3-(3,5-difluorophenyl)acrylic acid 
• 176504-51-1 methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(3,5-difluorophenyl) acrylate 

Relevant articles and documents

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

Palladium-catalyzed synthesis of aldehydes from aryl halides and tert-butyl isocyanide using formate salts as hydride donors

An efficient one-pot palladium-catalyzed hydroformylation of aryl halides to produce aromatic aldehydes has been achieved, employing tert-butyl isocyanide as a C1 resource and formate salt as a hydride donor without any additional bases. Characterized by its mild reaction conditions, easy operation and lower toxicity, this reaction can tolerate a wide array of functional groups with moderate to excellent yields.

Palladium-catalyzed formylation of aryl halides with tert -butyl isocyanide

A novel palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH has been demonstrated, which provides a strategy toward important aldehydes with moderate to excellent yield. The advantage of this reaction includes milder conditions, convenient operation, lower toxicity, and wide functional group tolerance.