132995-08-5Relevant academic research and scientific papers
Racemization of secondary alcohols catalyzed by ruthenium: Application to chemoenzymatic dynamic resolution
Merabet-Khelassi, Mounia,Vriamont, Nicolas,Aribi-Zouioueche, Louisa,Riant, Olivier
, p. 1790 - 1796 (2011)
In this paper, we have shown that the [RuCl2(p-cymene)] 2 complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2(p-cymene)]2/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out dynamic kinetic resolution experiments on rac-phenylethanol. This led us to identify the best conditions for effective DKR, which was then applied to various secondary benzylic and aliphatic alcohols. It was thus possible to obtain (R)-1-cyclohexylethyl acetate from rac-1-cyclohexylethanol in quantitative conversion and with high enantioselectivity (98%).
RING-CHAIN TAUTOMERISM IN 1,3-THIAZOLIDINES
Fueloep, Ferenc,Mattinen, Jorma,Pihlaja, Kalevi
, p. 6545 - 6552 (2007/10/02)
NMR spectroscopy was applied to study ring-chain tautomeric equilibria in several substituted 1,3-thiazolidines.The system highly prefers the ring form and only in the case of 2-(2'-hydroxy-5'-bromophenyl)-1,3-benzothiazoline (2d) 1H and 13C NMR spectra r
