132996-03-3Relevant academic research and scientific papers
Synthesis of Segments of the GnRH-Associated Peptide
Somlai, Csaba,Koenig, Wolfgang,Knolle, Jochen
, p. 1055 - 1062 (2007/10/02)
The 56 amino acid containing GnRH-associated peptide (GAP) may be prepared by a combination of fragment condensation and solid-phase peptide synthesis (SPPS).The solution-phase synthesis of the fragments 1-9 is described.Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group.The C-terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS.Key Words: Gonadoliberin-releasing hormone / Peptides
