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71989-23-6 Usage


Fmoc-L-Isoleucine, also known as N-(9-fluorenylmethoxycarbonyl)-L-isoleucine, is an unnatural amino acid that is structurally similar to the naturally occurring L-isoleucine. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, which is commonly used in solid-phase peptide synthesis. This modification allows for the efficient synthesis of complex peptide structures and contributes to its unique properties and applications in various fields.


Used in Pharmaceutical Industry:
Fmoc-L-Isoleucine is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure allows for the development of novel drug candidates with improved pharmacological properties, such as enhanced stability, bioavailability, and target specificity.
Used in Peptide Synthesis:
Fmoc-L-Isoleucine is used as a building block in the synthesis of peptides and peptidomimetics. The Fmoc protecting group enables the stepwise assembly of peptide chains through solid-phase peptide synthesis, allowing for the efficient and controlled synthesis of complex peptide structures.
Used in Research and Development:
Fmoc-L-Isoleucine is utilized in research and development for the study of protein structure, function, and interactions. Its unique properties make it a valuable tool for investigating the role of amino acids in protein folding, stability, and function, as well as for the development of new methodologies in peptide synthesis and modification.

Check Digit Verification of cas no

The CAS Registry Mumber 71989-23-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,9,8 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 71989-23:
166 % 10 = 6
So 71989-23-6 is a valid CAS Registry Number.

71989-23-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (F0294)  N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine  

  • 71989-23-6

  • 5g

  • 280.00CNY

  • Detail
  • TCI America

  • (F0294)  N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine  

  • 71989-23-6

  • 25g

  • 790.00CNY

  • Detail
  • Alfa Aesar

  • (B21154)  N-Fmoc-L-isoleucine, 98%   

  • 71989-23-6

  • 1g

  • 108.0CNY

  • Detail
  • Alfa Aesar

  • (B21154)  N-Fmoc-L-isoleucine, 98%   

  • 71989-23-6

  • 5g

  • 303.0CNY

  • Detail
  • Alfa Aesar

  • (B21154)  N-Fmoc-L-isoleucine, 98%   

  • 71989-23-6

  • 25g

  • 1285.0CNY

  • Detail
  • Aldrich

  • (47628)  Fmoc-Ile-OH  ≥98.0% (T)

  • 71989-23-6

  • 47628-50G-F

  • 604.89CNY

  • Detail
  • Aldrich

  • (47628)  Fmoc-Ile-OH  ≥98.0% (T)

  • 71989-23-6

  • 47628-250G-F

  • 2,130.57CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Fmoc-L-Isoleucine

1.2 Other means of identification

Product number -
Other names FMOC-L-Isoleucine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71989-23-6 SDS

71989-23-6Relevant articles and documents

Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety

Zhu, Lunan,Zhu, Junchen,Sun, Xiaotong,Wu, Yaling,Wang, Huiying,Cheng, Lingping,Shen, Jiawei,Ke, Yanxiong

, p. 1080 - 1090 (2020/05/25)

Novel chiral selectors based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin connecting quinine (QN) or quinidine (QD) moiety were synthesized and immobilized on silica gel. Their chromatographic performances were investigated by comparing to the 3,5-dimethyl phenylcarbamoylated β-cyclodextrin (β-CD) chiral stationary phase (CSP) and 9-O-(tert-butylcarbamoyl)-QN-based CSP (QN-AX). Fmoc-protected amino acids, chiral drug cloprostenol (which has been successfully employed in veterinary medicine), and neutral chiral analytes were evaluated on CSPs, and the results showed that the novel CSPs characterized as both enantioseparation capabilities of CD-based CSP and QN/QD-based CSPs have broader application range than β-CD-based CSP or QN/QD-based CSPs. It was found that QN/QD moieties play a dominant role in the overall enantioseparation process of Fmoc-amino acids accompanied by the synergistic effect of β-CD moiety, which lead to the different enantioseparation of β-CD-QN-based CSP and β-CD-QD-based CSP. Furthermore, new CSPs retain extraordinary enantioseparation of cyclodextrin-based CSP for some neutral analytes on normal phase and even exhibit better enantioseparation than the corresponding β-CD-based CSP for certain samples.

Fmoc-OPhth, the reagent of Fmoc protection

Yoshino, Ryo,Tokairin, Yoshinori,Kikuchi, Mari,Konno, Hiroyuki

supporting information, p. 1600 - 1603 (2017/04/03)

Fmoc-OSu has been widely used for Fmoc protection of amino groups, especially amino acids, in solid phase peptide synthesis. However, it has been recognized that Fmoc-βAla-OH is formed as a by-product via the Lossen rearrangement during the reaction. Since we reconfirmed the formation of Fmoc-βAla-OH during the preparation of Fmoc-AA-OH by Fmoc-OSu, Fmoc-OPhth was designed and synthesized as a new Fmoc reagent to avoid the formation of Fmoc-βAla-OH. Furthermore, Fmoc protection by Fmoc-OPhth and Fmoc-SPPS were evaluated. The various Fmoc-amino acids prepared by Fmoc-OPhth were carried out in good yields and these are applicable in Fmoc-SPPS.

Aqueous MW eco-friendly protocol for amino group protection

Nardi,Cano, N. Herrera,Costanzo,Oliverio,Sindona,Procopio

, p. 18751 - 18760 (2015/06/15)

In this paper a new catalyst-free and on-water method for protection of amines and amino acids with di-tert-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.

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