133-67-5 Usage
Chemical Properties
Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
Originator
Naqua,Schering,US,1960
Uses
Different sources of media describe the Uses of 133-67-5 differently. You can refer to the following data:
1. diuretic, antihypertensive
2. Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
3. Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
Manufacturing Process
A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9
grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was
heated at the boiling temperature and under reflux for 30 minutes. The
reaction mixture was thereafter poured into a mixture of ice and water to
precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro-
1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to
270°C with decomposition.
Therapeutic Function
Diuretic
Check Digit Verification of cas no
The CAS Registry Mumber 133-67-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 133-67:
(5*1)+(4*3)+(3*3)+(2*6)+(1*7)=45
45 % 10 = 5
So 133-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
