1330059-29-4

Basic information

• Product Name: N-tert-butoxycarbonyl-L-phenylalanine 9-fluorenylmethyl thioester
• Synonyms: N-tert-butoxycarbonyl-L-phenylalanine 9-fluorenylmethyl thioester
• CAS NO: 1330059-29-4
• Molecular Weight: 459.609
• Mol File: 1330059-29-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butoxycarbonyl-L-phenylalanine 9-fluorenylmethyl thioester(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butoxycarbonyl-L-phenylalanine 9-fluorenylmethyl thioester(1330059-29-4)
• EPA Substance Registry System: N-tert-butoxycarbonyl-L-phenylalanine 9-fluorenylmethyl thioester(1330059-29-4)

Safety Data

• Hazardous Substances Data: 1330059-29-4(Hazardous Substances Data)

Upstream product

• 957753-00-3 (9H-fluoren-9-yl)methanethiol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 78605-47-7 N-tert-butoxycarbonyl-L-phenylalanyl-L-alanine ethyl ester 
• 81000-39-7 (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid 
• 1428441-29-5 C₂₃H₂₁NOS*C₂HF₃O₂ 
• 1417995-01-7 C₄₈H₄₈N₄O₆S 
• 1428441-24-0 C₂₇H₂₇N₃O₃S*C₂HF₃O₂ 
• 1417995-00-6 C₃₂H₃₅N₃O₅S 

Relevant articles and documents

In situ carboxyl activation using a silatropic switch: A new approach to amide and peptide constructions

The novel reactivity of O-silylthionoesters with amine nucleophiles to generate oxoamides (rather than thioamides) is described. A straightforward first-generation trimethylsilylation protocol using bistrimethylsilylacetamide (BSA) combined with the unique reactivity of the O-silylthionoesters toward 1° and 2° amines to generate oxoamides provides the simplest means of activating a thiol acid for peptide bond formation at neutral pH. Excellent stereoretention is observed.