1417995-01-7Relevant academic research and scientific papers
Rapid formation of N-glycopeptides via Cu(II)-promoted glycosylative ligation
Joseph, Ryan,Dyer, Frank Brock,Garner, Philip
supporting information, p. 732 - 735 (2013/03/29)
Herein is described the chemoselective Cu(II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines; (2) it is remarkably fast, going to completion in under 30 min; and (3) it produces glycopeptides without attendant aspartimide formation.
