133024-37-0Relevant articles and documents
Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene
Kumamoto, Takuya,Aoyama, Naho,Nakano, Satoko,Ishikawa, Tsutomu,Narimatsu, Shizuo
, p. 791 - 795 (2007/10/03)
Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.
Synthesis of potential Naftopidil metabolites
Kutscher,Engel,Fleischhauer,Niebch
, p. 803 - 806 (2007/10/02)
The synthesis of four proposed metabolites 1-4 of Naftopidil, a selective α1-antagonist, is reported. These compounds comprise hydroxylated and demethylated derivatives and a cleavage product of Naftopidil.