73661-06-0

Upstream product

• 571-60-8 1,4-Dihydroxynaphthalene 
• 100-44-7 benzyl chloride 
• 620-05-3 iodomethylbenzene 
• 70662-30-5 1-acetoxy-4-hydroxynaphthalene 
• 5697-00-7 1,4-diacetoxynaphthalene 
• 352200-67-0 acetic acid 4-benzyloxy-naphthalen-1-yl ester 
• 100-51-6 benzyl alcohol 

Downstream Products

• 352200-70-5 (S)-(+)-1-benzyloxy-4-(oxiranylmethoxy)naphthalene 
• 352200-69-2 (R)-(-)-1-benzyloxy-4-(oxiranylmethoxy)naphthalene 
• 133024-37-0 (+/-)-1-benzyloxy-4-(oxiranylmethoxy)naphthalene 
• 133024-36-9 (naphthyl)hydroxy-naftopidil 

Relevant academic research and scientific papers

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.

Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

Process for the two-stage oxidation dyeing of keratin fibers with a manganese complex or salt and a 4-substituted 1-naphthol, and dyeing kit

A process for the two-stage oxidation dyeing of keratin fibers by applying to the keratin fibers: in a first stage, at least one composition A containing at least one manganese salt and/or a manganese complex, in a second stage, at least one composition B having a pH of greater than or equal to 6, and resulting from the extemporaneous mixing of at least one composition B1 containing at least one 4-substituted 1-naphthol and at least one composition B2 containing at least one oxidizing agent, and corresponding multi-compartment dyeing kit.

Synthesis of potential Naftopidil metabolites

The synthesis of four proposed metabolites 1-4 of Naftopidil, a selective α1-antagonist, is reported. These compounds comprise hydroxylated and demethylated derivatives and a cleavage product of Naftopidil.

Piperazine derivatives, uses thereof and pharmaceutical compositions containing them

The present invention provides compounds of the general formula: STR1 wherein R1 is a hydroxyl group or a methoxy radical, R2 is a hydrogen atom or a hyroxyl group and R3 is a hydrogen atom or a hydroxyl group, with the proviso that R2 and R3 are not simultaneously hydrogen atoms when R1 is a methoxy radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

Synthesis of 4'-Hydroxypropranolol Sulfate, a Major Non-β-Blocking Propranolol Metabolite in Man

4'-Hydroxypropranolol sulfate (8) was recently identified as a major metabolite of propranolol (Inderal).In order to confirm the structure and to further study disposition and biological activity, he have synthesized 8 with use of 1,4-naphthoquinone (1) as the starting material.Reduction and alkylation with benzyl iodide gave 4-(benzyloxy)naphthol (3).Sulfation and chlorosulfuric acid in N,N-dimethylaniline gave potassium 1-(benzyloxy)-4-naphthol sulfate (4).Catalytic hydrogenation, alkylation with oxy>methyl>oxirane (6), and amination in isopropylamine gave 8.Racemic 8 was found to be 100-1000 times less potent than racemic propranolol as a β-adrenergic receptor blocking agent in the dog.

Dimeric Naphthoquinones, II. - Simple and Regioselective Synthesis of Naphthoquinol Monoalkyl Ethers via 2,3-Dihydronaphthoquinones

On catalysis of hydrogen chloride or thionyl chloride, 1,4-naphthalenediole (2a) reacts with primary or secundary alcohols via the tautomeric 2,3-dihydronaphthoquinone (9) to give naphthoquinol monoalkyl ethers 2b-n in high yields.The influence of the substitution pattern on the regioselectivity of the reaction has been investigated.