133030-40-7Relevant academic research and scientific papers
NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES
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Page/Page column 79, (2008/06/13)
The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen at
Benzopyridazinone and pyridopyridazinone compounds
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, (2008/06/13)
Benzo or pyridopyridazinones and pyridazinthiones of the formula STR1 wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R1 is hydrogen, lower alkyl, aryl, aralkyl, heterocyclo, heterocyclo lower-alkyl, heteroaryl, or heteroaralkyl; R2, R3, R4, R5 and R6 are independently selected from hydrogen, lower alkyl, halo, carboxy, alkoxycarbonyl, carbamoyl, lower-alkyl carbonyl, halocarbonyl, thiomethyl, trifluoromethyl, cyano or nitro; or a pharmaceutically acceptable ester, ether or salt thereof, have been found to be useful as an anti-inflammatory, antasthmatic, immunosuppressive, anti-allograft rejection, anti-graft-vs-host rejection, autoimmune disease or analgetic agent(s).
Application of Organolithium and Related Reagents in Synthesis, Part VI . A General Study of the Lithiation of Secondary Picoline- and Isonicotine Amides
Epsztajn, Jan,Jozwiak, Andrzej,Czech, Krzysztof,Szczesniak, Aleksandra K.
, p. 909 - 921 (2007/10/02)
The lithiation of secondary picoline- (1) and isonicotine-amides (2) and the subsequent reaction of the corresponding (N- and 3-)lithiated amides (3 and 4) with N,N-dimethylbenzamide towards the synthesis of the C3-benzoylated picoline (12a) an
