133036-75-6

Basic information

• Product Name: 2-benzamido-4,5-dihydro-3-thiophenecarboxamide
• Synonyms: 2-benzamido-4,5-dihydro-3-thiophenecarboxamide
• CAS NO: 133036-75-6
• Molecular Weight: 248.305
• Mol File: 133036-75-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-benzamido-4,5-dihydro-3-thiophenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzamido-4,5-dihydro-3-thiophenecarboxamide(133036-75-6)
• EPA Substance Registry System: 2-benzamido-4,5-dihydro-3-thiophenecarboxamide(133036-75-6)

Safety Data

• Hazardous Substances Data: 133036-75-6(Hazardous Substances Data)

Upstream product

• 133036-76-7 tetrahydro-2-oxo-3-thiophenecarbonitrile 
• 52989-46-5 2-amino-4,5-dihydro-3-thiophenecarbonitrile 
• 159975-97-0 3-acetyl-5,6-dihydro-2-phenylthieno<2,3-d>pyrimidin-4(3H)-one 
• 159976-03-1 N-acetyl-2-benzamido-4,5-dihydro-3-thiophenecarboxamide 
• 133036-77-8 2-amino-4,5-dihydrothiophene-3-carboxamide 
• 98-88-4 benzoyl chloride 
• 51991-77-6 2-benzamido-4,5-dihydro-3-thiophenecarbonitrile 

Relevant articles and documents

Synthesis of 3-Acyl-5,6-dihydro-2-phenylthieno(-furo-)pyrimidin-4(3H)-ones

The reactions of 2-benzamido-4,5-dihydro-3-thiophene(-3-furan-)carbonitriles 1a-c (and 11a-c) with acetic (or propionic) anhydride in the presence of tin(IV) chloride give the corresponding 3-acetyl-5,6-dihydro-2-phenylthieno(-furo-)pyrimidin-4(3H)-ones 2a-c (and 12a-c) or 5,6-dihydro-2-phenyl-3-propionylthieno(-furo-)pyrimidin-4(3H)-ones 3a-c (and 13a-c).Hydrolysis of compounds 2a-c (and 12a-c) or 3a-c (and 13a-c) leads to the corresponding N-acetyl-2-benzamido-4,5-dihydro-3-thiophene-(-3-furan-)carboxamides 4a-c (and 14a-c) or 2-benzamido-4,5-dihydro-N-propionyl-3-thiophene-(-3-furan-) carboxamides 5a-c (and 15a-c).The reaction of compounds 4a,b (or 14a,b) with acid anhydrides in the presence of potassium carbonate or triethylamine gives the corresponding 3-acyl-2-benzamido-4,5-dihydrothiophenes (or furans) 9, 10, 16, and 17. - Key words: Thiophenes / Thienopyrimidines / Furans / Furopyrimidines