133044-59-4

Upstream product

• 934-34-9 2(3H)-Benzothiazolone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 913969-72-9 4-{2-[6-(4-methoxybenzoyl)-2(3H)-benzothiazolon-3-yl]ethoxy}benzaldehyde 
• 1429051-30-8 C₁₇H₁₃NO₅S 
• 1402702-73-1 6-(4-methoxybenzoyl)-3-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3H)-one 
• 1429051-26-2 C₁₉H₁₇NO₅S 
• 133044-62-9 6-[1-Hydroxy-1-(4-Methoxyphenyl)Methyl]Benzothiazolinone 
• 133044-61-8 6-(4-hydroxybenzoyl)benzothiazolinone 
• 353282-01-6 dimethyl 4-{2-[6-(4-methoxybenzoyl)-2(3H)-benzothiazolon-3-yl]ethoxy}benzylidenemalonate 
• 353282-08-3 dimethyl 2-{4-[2-(6-(4-methoxybenzoyl)-2-oxo-1,3-benzothiazol-3(2H)-yl)ethoxy]-benzyl}malonate 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 1,3-benzothiazol-2(3 H)-one derivatives and analysis of their antinociceptive activity

A rapid and efficient method was developed for synthesis of 6-acyl-1,3-benzothiazol-2(3H)-one derivatives under microwave irradiation (MWI) conditions. The reaction times were shortened compared to conventional heating. Additionally, we synthesized acetic acid and acetamide derivatives of 1,3-benzothiazol-2(3H)-one, 6-acyl-1,3-benzothiazol-2(3H)-one, 5-chloro-1,3-benzothiazol-2(3H)-one and 6-acyl-5-chloro-1,3-benzothiazol-2(3H)- one with the microwave-assisted method and analyzed their antinociceptive activity with the tail flick, tail clip, hot plate and writhing tests. Among the synthesized compounds, 3-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-1,3- benzothiazol-2(3H)-one (6a), 5-chloro-3-{2-oxo-2-[4-(propan-2-yl) piperazin-1-yl]ethyl}-1,3-benzothiazol-2(3H)-one (7e) and 3-[2-(4- butylpiperazin-1-yl)-2-oxoethyl]-5-chloro-1,3-benzothiazol-2(3H)-one (8e) showed significant antinociceptive activity in the tail clip, tail flick, hot plate and writhing tests. Supporting Information available online at http://www.thieme-connect.de/ejournals/toc/amf.

Benzazoles. 2. Relative activity of catalysts and 4-substituted benzoyl chlorides in the acylation of benzothiazolin-2-ones

A series has been established for the relative activity of catalysts and 4-substituted benzoyl chlorides on acylation of benzothiazolin-2-ones with 4-substituted benzoyl chlorides in the presence of FeCl3, FeCl3·6H2O, FeCl3·12H2O, ZnCl2, ZnCl2·2H2O, AlCl3, and iron acetylacetonate, as a function of the degree of acidity of the catalyst and the electrophilicity of the acylating agent.

Benzothiazolinone compounds

Compounds of general formula (I): STR1 in which: R1 represents a hydrogen atom or a lower alkyl group, R2 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstitute