133052-53-6

Basic information

• Product Name: methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate
• Synonyms: methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate
• CAS NO: 133052-53-6
• Molecular Weight: 401.303
• Mol File: 133052-53-6.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate(133052-53-6)
• EPA Substance Registry System: methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate(133052-53-6)

Safety Data

• Hazardous Substances Data: 133052-53-6(Hazardous Substances Data)

Upstream product

• 5851-44-5 2-n-butylbenzimidazole 
• 128577-48-0 methyl 2-bromo-4-(bromomethyl)benzoate 

Downstream Products

• 133052-88-7 2-Bromo-4-(2-butyl-benzoimidazol-1-ylmethyl)-benzoic acid 

Relevant articles and documents

Benz[4,5]imidazole-containing angiotensin antagonists

The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The heterocyclic compounds antagonize the actions of angiotensin II and are of value in treating diseases or medical conditions such as hypertension and congestive heart failure in warm-blooded animals. The invention further includes processes for the manufacture of the novel compounds and their use in medical treatment.

New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives

On the basis of an extension of the literature lead 1, a series of benzimidazoles have been synthesized and shown to be angiotensin II (AII) receptor antagonists. The structure-activity relationships of these new antagonists have been explored and the key