5851-44-5

Basic information

• Product Name: 2-butyl-benzimidazol
• Synonyms: 2-butyl-1h-benzimidazol;2-butyl-benzimidazol;1H-Benzimidazole,2-butyl-(9CI);1H-BenziMidazole, 2-butyl-;2-butyl-1H-benzo[d]iMidazole;BENZIMIDAZOLE, 2-BUTYL-;2-(But-1-yl)-1H-benzimidazole
• CAS NO: 5851-44-5
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.246
• Product Categories: BENZIMIDAZOLE
• Mol File: 5851-44-5.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 358.3°C at 760 mmHg
• Flash Point: 181.3°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 5.3E-05mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 2-butyl-benzimidazol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-benzimidazol(5851-44-5)
• EPA Substance Registry System: 2-butyl-benzimidazol(5851-44-5)

Safety Data

• Hazardous Substances Data: 5851-44-5(Hazardous Substances Data)

Usage

General Description

2-butyl-benzimidazol is a chemical compound with the molecular formula C11H14N2. It is a benzimidazole derivative, which is often used as an intermediate in the synthesis of pharmaceutical compounds. 2-butyl-benzimidazol is known for its potential therapeutic effects, including anti-cancer and anti-inflammatory properties. It has been studied for its role in inhibiting the growth of cancer cells and reducing inflammation in various medical conditions. Additionally, this compound has been used as a component in the synthesis of molecules with potential activity against various diseases, making it an important compound in medicinal chemistry research.

InChI:InChI=1/C11H14N2/c1-2-3-8-11-12-9-6-4-5-7-10(9)13-11/h4-7H,2-3,8H2,1H3,(H,12,13)

Upstream product

• 110-62-3 pentanal 
• 95-54-5 1,2-diamino-benzene 
• 110-59-8 pentanonitrile 
• 109-52-4 valeric acid 
• 13820-09-2 trimethyl orthovalerate 
• 999-09-7 ethyl valerimidate 
• 71-41-0 pentan-1-ol 
• 638-29-9 n-valeryl chloride 
• 1039810-78-0 2-iodo-N-pentylaniline 
• 110-53-2 1-Bromopentane 
• 615-43-0 2-iodophenylamine 
• 919-29-9 triethyl orthovalerate 
• 88-74-4 2-nitro-aniline 
• 613-29-6 N-Dibutylaniline 

Downstream Products

• 133052-51-4 methyl 4'-[(2-butyl-1H-benzimidazol-1-yl)methyl]benzoate 
• 133052-57-0 methyl-4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-methylbenzoate 
• 133052-53-6 methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-2-bromobenzoate 
• 133052-54-7 3-Bromo-4-(2-butyl-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester 
• 133052-50-3 methyl 4'-[(2-butyl-1H-benzimidazol-1-yl)methyl]biphenyl-2-carboxylate 
• 133052-55-8 methyl 4-[(2-butyl-1H-benzimidazol-1-yl)methyl]-3-nitrobenzoate 
• 194417-13-5 2-[5-(2-Butyl-benzoimidazol-1-ylmethyl)-thiophen-2-yl]-benzonitrile 
• 194416-98-3 2-[5-(2-Butyl-benzoimidazol-1-ylmethyl)-thiophen-2-yl]-benzoic acid methyl ester 
• 133075-99-7 4'-[(2-butyl-1H-benzimidazol-1-yl)methyl]biphenyl-2-carboxylic acid 
• 135070-91-6 2-n-Butyl-1-{(5'-chloro-2'-cyanobiphenyl-4-yl)methyl]benzimidazole 
• 1264932-34-4 C₂₁H₂₆N₂O₂S 
• 1264932-40-2 C₂₀H₂₄N₂O₂S 
• 1264932-37-7 C₁₉H₂₂N₂O₂S 
• 1264932-31-1 C₁₇H₁₇ClN₂O₂S 

Relevant articles and documents

Photochemical Synthesis of Benzimidazoles from Diamines and Aldehydes

An efficient, green, cheap, and metal-free photochemical protocol for the synthesis of benzimidazoles has been developed. 2,2-Dimethoxy-2-phenylacetophenone was employed as the photoinitiator and CFL lamps were used as the light source, leading to the cyc

Metal-organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway

Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH2-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH2-MIL-125(Ti) MOF surface through electron deficient Ti4+ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.

Direct synthesis of 2-substituted benzimidazoles: Via dehydrogenative coupling of aromatic-diamine and primary alcohol catalyzed by a Co complex

A Co(ii) complex with a stable structure was designed and synthesized with quinalic acid and Co (OAc)2·4H2O. The single crystal structure of the complex was characterized by X-ray diffraction. A dehydrogenative coupling of aromatic diamines and primary alcohols was developed by using the Co(ii) complex as the catalyst to synthesize 2-substituted benzimidazole. A series of 2-substituted benzimidazoles were obtained with good to excellent yields under mild reaction conditions. In addition, a compound with inhibitory Parkinson's activity was synthesized on a gram-scale by using this method. Finally, the reaction mechanism was proposed and the energy changes in the reaction process were simulated by density functional theory (DFT).