133055-08-0

Basic information

• Product Name: Benzene, 1-(2,2-dimethyl-3-phenylpropyl)-2-methyl-
• CAS NO: 133055-08-0
• Molecular Formula: C18H22
• Molecular Weight: 238.373
• Mol File: 133055-08-0.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2,2-dimethyl-3-phenylpropyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dimethyl-3-phenylpropyl)-2-methyl-(133055-08-0)
• EPA Substance Registry System: Benzene, 1-(2,2-dimethyl-3-phenylpropyl)-2-methyl-(133055-08-0)

Safety Data

• Hazardous Substances Data: 133055-08-0(Hazardous Substances Data)

Upstream product

• 40548-64-9 3-iodo-2,2-dimethyl-1-phenylpropane 
• 33872-80-9 o-tolyl magnesium chloride 
• 932-31-0 ortho-tolylmagnesium bromide 

Relevant articles and documents

Nickel-Mediated Cross-Coupling of Unactivated Neopentyl Iodides with Organozincs

(dppf)NiCl2 catalyzes the cross-coupling of unactivated primary neopentyl iodides with diorganozinc reagents.The zinc nucleophiles are formed by the treatment of ZnCl2*dioxane with 2 mol equiv of a Grignard reagent in an etheral solvent.The cross-coupling works optimally for diorganozincs formed from aryl chlorides or CH3MgCl.Use of aryl bromides can cause reduction and/or reductive dimerization of the electrophile.The analogous reaction with (CH3)2CuMgCl in either the presence or the absence of Group 10 metal catalysts failed to afford reasonable yields of cross-coupled products.The diorganozinc methodology overcomes many of the side reactions observed with the (dppf)NiCl2-mediated cross-coupling of Grignard reagents.

Nickel-catalyzed cross-coupling of unactivated neopentyl iodides with Grignard reagents

Primary neopentyl iodides react with aryl Grignard reagents in the presence of 10 mol% (dppf)NiCl2 to give the cross-coupled product.