1330787-01-3Relevant articles and documents
Regiospecific epoxide opening: A facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives
Chouhan, Mangilal,Senwar, Kishna Ram,Sharma, Ratnesh,Grover, Vikas,Nair, Vipin A.
, p. 2553 - 2560 (2011/10/12)
A mild and eco-friendly method has been developed for aminolysis of 3-oxirane-indolin-2-ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones. An enhancement in reaction rate was observed when water was used as the reaction medium. The reactions proceed regiospecifically to open the epoxide ring from the less-substituted end.