13308-13-9

Basic information

• Product Name: (2R,3S)-2,3-dihydroxy-4-[(methylsulfonyl)oxy]butyl methanesulfonate
• Synonyms: Erythritol, 1,4-bis(methanesulfonate); Erythritol, 1,4-dimethanesulfonate
• CAS NO: 13308-13-9
• Molecular Formula: C₆H₁₄O₈S₂
• Molecular Weight: 278.3006
• Mol File: 13308-13-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 607°C at 760 mmHg
• Flash Point: 320.9°C
• Density: 1.562g/cm³
• Vapor Pressure: 2.86E-17mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: (2R,3S)-2,3-dihydroxy-4-[(methylsulfonyl)oxy]butyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-2,3-dihydroxy-4-[(methylsulfonyl)oxy]butyl methanesulfonate(13308-13-9)
• EPA Substance Registry System: (2R,3S)-2,3-dihydroxy-4-[(methylsulfonyl)oxy]butyl methanesulfonate(13308-13-9)

Safety Data

• Hazardous Substances Data: 13308-13-9(Hazardous Substances Data)

Usage

General Description

(2R,3S)-2,3-dihydroxy-4-[(methylsulfonyl)oxy]butyl methanesulfonate, also known as Mesylglycol, is a chemical compound that is commonly used as a protecting group for alcohols in organic synthesis. It is a derivative of mesylate, a functional group that is often used as a leaving group in organic reactions. Mesylglycol is highly reactive and can be easily cleaved under mild conditions, making it a useful tool in the synthesis of complex organic molecules. Its properties also make it a valuable intermediate in the production of pharmaceuticals and agrochemicals. Additionally, it is also used as a solvent in some chemical processes. Overall, Mesylglycol plays a crucial role in various chemical reactions and is an important component in the field of organic chemistry.

Upstream product

• 4248-74-2 ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) dimethanesulfonate 
• 75-75-2 methanesulfonic acid 
• 298-18-0 (S,S)-diepoxybutane 
• 299-70-7 threo-1,4-dibromo-2,3-butanediol 
• 2386-52-9 silver methanesulfonate 
• 91138-54-4 2,3-Di-O-acetyl-1,4-di-O-methansulfonylerythrit 
• 1947-59-7 meso-1,4-dibromo-butane-2,3-diol 
• 909878-64-4 meso-erythritol 
• 1464-53-5 rac-1,2,3,4-diepoxybutane 
• 4248-74-2 2,3-O-Isopropyliden-DL-threitol-1,4-bis-methansulfonat 
• 94730-27-5 (4S,5S)-2-phenyl-4,5-di(methanesulphonyloxymethyl)-1,3-dioxolan 
• 15410-44-3 (2R,3R)-1,4-dibromobutane-2,3-diol 
• 38279-61-7 meso-2,3-O-isopropylidene-1,4-di-O-(methanesulfonyl)butane-1,2,3,4-tetrol 

Downstream Products

• 4211-07-8 L-4,5-Bismethylsulfonyloxymethyl-1,3,2-dioxathiolane 2-Oxide 
• 298-18-0 (S,S)-diepoxybutane 
• 564-00-1 (R,R)-butane-1,2:3,4-bisoxide 
• 4251-91-6 Di-2,3-O-carbethoxy-L-threitol-1,4-bismethanesulfonate 
• 87338-21-4 ((2S,3S)-1,4-dioxaspiro[4.5]decane-2,3-diyl)bis(methylene) dimethanesulfonate 

Relevant articles and documents

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A PROCESS FOR THE PREPARATION OF TREOSULFAN

The present invention relates to a process for the preparation of Treosulfan using sodium borohydride and iodine as reducing agent, which is less hazardous and convenient as compared to the reagents used in the prior art. The invention also relates to a novel intermediate to obtain Treosulfan in high yield and high purity.

Truly catalytic and chemoselective cleavage of benzylidene acetal with phosphomolybdic acid supported on silica gel

Phosphomolybdic acid supported on silica gel provides a truly catalytic method for the chemoselective cleavage of benzylidene acetals having sensitive functional groups under mild conditions. It is easy to perform on large scale owing to minimal catalyst loading (0.5 mol-%). Several sensitive functional groups such as TBDPS ether, -OMs, -OAc, allyl ether, N-Boc, N-Fmoc and N-Cbz are stable under the reaction conditions. In addition, benzylidene acetal is selectively cleaved in the presence of isopropylidene ketal. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.