87338-21-4

Usage

Primary Use

Crosslinking agent in the production of epoxy resins and adhesives

Structure

Central 1,4-dioxaspiro[4.5]decane ring with two methylene groups attached, each bonded to a dimethanesulfonate group

Bonding Ability

Known for forming strong chemical bonds with other molecules

Industrial Applications

Wide range, particularly in the manufacture of reinforced plastics and composites

Hazardous Substance

Considered hazardous due to potential toxicity and environmental impact

Handling Precaution

Should be handled with caution to minimize health and environmental risks

Upstream product

• 60989-82-4 (2S,3S)-(–)-2,3-di(hydroxymethyl)-1,4-dioxaspiro[4.5]decane 
• 124-63-0 methanesulfonyl chloride 
• 299-74-1 treosulfan 

Downstream Products

• 105206-96-0 9,10-(1,1-cyclohexanediyldioxy)-1,4,7-tris(4-tolylsulfonyl)-1,4,7-triazacycloundecane 
• 87338-20-3 cyclohexanone ketal of (2S,3S)-1,4-bis(4-tolylsulfonyl)-1,4-diaza-2,3-dihydroxycyclotetradecane 
• 105206-80-2 2,3-bis<(phenylthio)methyl>-1,4-dioxaspiro<4,5>decane 

Relevant academic research and scientific papers

Enantioselective α-Hydroxylation by Modified Salen-Zirconium(IV)-Catalyzed Oxidation of β-Keto Esters

The highly enantioselective α-hydroxylation of β-keto esters using cumene hydroperoxide (CHP) as the oxidant was realized by a chiral (1S,2S)-cyclohexanediamine backbone salen-zirconium(IV) complex as the catalyst. A variety of corresponding chiral α-hydroxy β-keto esters were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98% ee). The zirconium-catalyzed enantioselective α-hydroxylation of β-keto esters was scalable, and the zirconium catalyst was recyclable. The reaction can be performed in gram scale, and corresponding chiral products were acquired in 95% yield and 99% ee.

Platinum(II) complex and processes for preparing the same

Disclosed herein are novel platinum(II) complexes having a potent anti-tumor activity which are represented by the formula (1), STR1 wherein R1 and R2, which may be the same or different, are a hydrogen atom or a C1-4 alkyl group, respectively, or jointly form a cycloalkane group together with the carbon atom attached thereto; two Xs jointly form a group represented by formula (a) or (b) wherein, R3 is a hydrogen atom or a methyl group; R4 and R5, which may be the same or different, are a hydrogen atom or a C1-4 alkyl group, respectively, or jointly form a cyclobutane together with the carbon thereto; and the absolute configurations at the respective chiral centers in the 4,5-bis(aminomethyl)-1,3-dioxolane moiety are (4R,5R) or (4S,5S); processes for the preparing the same; and their use for treating animal or human cancer. Further, disclosed herein are novel intermediates useful for the preparation of the platinum(II) complexes and processes for preparing said intermediates.

Synthesis of Aza Macrocycles by Nucleophilic Ring Closure with Cesium Tosylamides

Long-chain diamines as their bis tosylamide derivatives are deprotonated by Cs2CO3 in dimethylformamide solution to give the dicesium salts.These react smoothly with various dibromides or dimesylates to afford the cyclic diamines as their tosyl derivatives.The yields, depending on the size of the ring, range between 25percent and 95percent of isolated product.The largest ring made, 1,12-diazaoctacosane (as the tosylamide derivative) was isolated in 60percent yield.The tosyl groups are readily removed with sodium amalgam in Na2HPO4-buffered methanolic solution.Chiral macrocyclic amines have also been prepared by using this cesium salt method.