133097-35-5Relevant academic research and scientific papers
Enantioselective synthesis of (S)-α-arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols
Thakur, Vinay V.,Sudalai
, p. 557 - 562 (2007/10/03)
A convenient synthetic route for the synthesis of three (S)-α-propionic acids, (5)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (5)-phenylpropionic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule.
