108781-65-3Relevant articles and documents
Oxidative decarboxylation of naproxen
Bosca,Martinez-Manez,Miranda,Primo,Soto,Vano
, p. 479 - 482 (1992)
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8/2-] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pl-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
Kinetics and pathways of the degradation of PPCPs by carbonate radicals in advanced oxidation processes
Chen, Chunyan,Fang, Jingyun,Guo, Kaiheng,Hua, Zhechao,Wang, Liping,Wu, Zihao,Zhou, Yujie
, (2020/08/10)
The carbonate radical (CO3??) is a typical secondary radical observed in engineering and natural aquatic systems. This study investigated the degradation kinetics of 20 pharmaceuticals and personal care products (PPCPs) by CO3?? and the transformation pathways of a typical PPCP (naproxen) that is susceptible to CO3??. CO3?? is highly selective for compounds containing aniline and phenolic hydroxyl groups as well as naphthalene rings, such as sulfamethoxazole, sulfamethazine, salbutamol, propranolol, naproxen, and macrolide antibiotics such as azithromycin, for which the second-order rate constants range from 5.6 × 107 M?1s?1 to 2.96 × 108 M?1s?1. A good linear relationship is observed between the natural logarithms of kCO3?? and the negative values of the Hammett Σσp+ constant for aromatic PPCPs, indicating that electron-donating groups promote the attack of benzene derivatives by CO3??. The contribution of CO3?? to naproxen degradation is significant in different processes such as UV/H2O2, UV/persulfate, UV/chlorine, and UV/monochloramine, in the presence of HCO3?, which compensates for the decreased contributions of primary radicals. In particular, the formation of CO3?? increases the first-order rate constant of naproxen by 127% in UV/monochloramine in the presence of 50 mM HCO3? compared to that without HCO3?. Natural organic matter (NOM) exerts a slight scavenging effect on CO3??, decreasing the inhibition effect of NOM on the degradation of naproxen by UV/H2O2 in the presence of HCO3?. The pathways involved in the transformation of naproxen by CO3?? include decarboxylation, hydroxylation, ketonization, demethylation and aldolization. In addition, the alteration of the genotoxicity during naproxen degradation by CO3?? was negligible.
Enantioselective synthesis of (S)-α-arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols
Thakur, Vinay V.,Sudalai
, p. 557 - 562 (2007/10/03)
A convenient synthetic route for the synthesis of three (S)-α-propionic acids, (5)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (5)-phenylpropionic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule.
