133100-87-5

Usage

Uses

Used in Scientific Research and Development:
4-Bromo-3-methyl-isoquinoline is used as a research compound for the investigation of new chemical reactions and processes. Its unique structure allows for the exploration of various chemical interactions and transformations, contributing to the advancement of chemical knowledge.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 4-bromo-3-methyl-isoquinoline is used as a key intermediate in the synthesis of complex chemical structures and pharmaceutical compounds. Its presence in these molecules can influence their properties and potential therapeutic applications, making it a valuable component in drug development.
Used in Laboratory Settings:
4-Bromo-3-methyl-isoquinoline is extensively used in laboratories, where its detailed physical properties and potential hazards can vary significantly based on the specific conditions and methods it is employed under. This versatility makes it a valuable tool for researchers working in a wide range of scientific disciplines.

Upstream product

• 1125-80-0 3-methylisoquinoline 

Downstream Products

• 161468-32-2 4-cyano-3-methyl-isoquinoline 
• 1254163-63-7 4-cyano-3-(3-methyl-isoquinolin-4-yl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES

The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+-O- or CR3; Y is N, N+-O- or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Imidazole and imidazoline derivatives and uses thereof

This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human α2 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where

Nature of the Reactions Involving 4-Haloisoquinolines and Amide Ion in Ammonia. Remarkable Competition between SRN1 Substitution and ? Complex Formation

4-Bromo- (1) or 4-chloroisoquinoline (3) in refluxing liquid ammonia containing amide and thiomethoxide reacts preferentially with the thiolate ion to give 4-(methylthio)isoquinoline (2) in high yield.The bromo substrate was shown to require amide ion in order to react with thiomethoxide ion, no reaction taking place in its absence.Substitution product is believed to form from both halides by an SRN1 mechanism.By contrast, 3-chloroisoquinoline under the same conditions of mixed anions gives 3-aminoisoquinoline.The role of amide ion and its addition to give ? complexes in these and other reactions of 4-halogenated isoquinolines in ammonia is discussed.