161468-32-2

Usage

Uses

Used in Pharmaceutical Research:
4-Cyano-3-methylisoquinoline is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Synthesis:
4-CYANO-3-METHYLISOQUINOLINE is also utilized as a building block in the synthesis of agrochemicals, playing a role in the creation of pesticides and other agricultural products to enhance crop protection and yield.
Used in Biological Imaging:
4-Cyano-3-methylisoquinoline is used as a fluorescent marker in biological imaging, aiding researchers in visualizing cellular and molecular processes due to its fluorescent properties.
Used in Material Sciences:
4-CYANO-3-METHYLISOQUINOLINE has been studied for its potential applications in material sciences, where it may contribute to the development of new materials with specific properties for various industrial applications.

Upstream product

• 133100-87-5 4-bromo-3-methylisoquinoline 
• 161468-36-6 N-(4-Cyano-3-methyl-1H-isochromen-1-yl)-acetamide 

Relevant academic research and scientific papers

Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity

Using AMD070 as a starting point for structural modification, a novel series of isoquinoline CXCR4 antagonists was developed. A structure-activity scan of alternate lower heterocycles led to the 3-isoquinolinyl moiety as an attractive replacement for benzimidazole. Side chain optimization in the isoquinoline series led to a number of compounds with low nanomolar anti-HIV activities and promising rat PK properties.

NOVEL 3-METHYL-7-BUTINYL-XANTHINES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS

The invention relates to novel substituted xanthines of general formula (I), wherein R1, R2, and X are defined as mentioned in the claims, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, which have valuable pharmaceutical properties, especially an inhibitive effect on the activity of the dipeptidyl peptidase-IV (DPP-IV) enzyme.

Acetylation of α-cyano-o-tolunitrile: Reinvestigation and convenient synthesis of isoquinolines

The product from the diacetylation of α-cyano-o-tolunitrile has now been assigned as an isocoumarin derivative. This is readily transformed into various 1-substituted-3-methylisoquinoline-4-carbonitriles by reaction with oxygen, nitrogen, carbon and hydrogen nucleophiles.