13311-77-8

Upstream product

• 91-19-0 2,3-diethynylquinoxaline 
• 917-54-4 methyllithium 
• 2379-55-7 2,3-dimethylquinoxaline 
• 78-93-3 butanone 
• 106-89-8 epichlorohydrin 
• 431-03-8 dimethylglyoxal 
• 95-54-5 1,2-diamino-benzene 
• 917-64-6 methyl magnesium iodide 
• 88-74-4 2-nitro-aniline 
• 4091-39-8 3-chloro-2-butanone 

Downstream Products

• 2379-55-7 2,3-dimethylquinoxaline 
• 1721-89-7 2,3-dimethylquinoline 
• 857763-04-3 2-(4-chlorophenethyl)-3-methylquinoxaline 

Relevant academic research and scientific papers

Facile Synthesis and Bioactivity of Novel N,N′-disubstituted-1,2,3,4-tetrahydroquinoxalines

A series of novel N,N'-disubstituted-1,2,3,4-tetrahydroquinoxalines were designed and synthesized by cyclization and acylation. The structures of all the novel compounds were confirmed by IR, 1H NMR, 13C NMR, and high-resolution mass

SELEKTIVE KOHLENSTOFF-KOHLENSTOFF-VERKNUEPFUNGEN MIT NUCLEOPHILEN THERMOLABILEN METHYLCOBALT-REAGENZIEN

Nonstabilized Co(II) methyl derivatives (MeCoCl, Me2Co, Me3CoLi, Me4CoLi2) are readily accessible in solution (THF, Et2O) by reaction of MeLi with CoCl2 at -78 deg C to -60 deg C.For checking the transmetallation process the "β-bromostyrene-ketone-test" is especially favorable.Characteristic features of the reactivity of the Co-reagents: High efficiency in the cross coupling with trans-β-bromo-styrene, high aldehyde-vs.-ketone selectivity in Et2O, methylation of 2-cyclohexenone mainly in β-position, the ate-complexes methylate carboxylic esters, but not tertiary carboxylic amides.

Asymmetric Transfer Hydrogenations of 2,3-Disubstituted Quinoxalines with Ammonia Borane

An asymmetric transfer hydrogenation of 2,3-disubstituted quinoxalines using a chiral frustrated Lewis pair of Piers' borane and (R)-tert-butylsulfinamide as the catalyst with ammonia borane as the hydrogen source has been successfully realized. For 2-alk

Switchable hydrogenation with a betaine-derived bifunctional Ir-NHC catalyst

A bifunctional iridium catalyst based on the 'uracil-abnormal NHC' hybrid ligand platform was developed for switchable hydrogenation of quinoxalines. Control studies suggested heterolytic H2 activation via a metal-ligand bifunctional operation to generate Ir-H and an adjacent protic O-H group for facile H+/H- transfer to quinoxaline. The presence of a base blocked the most essential H+-transfer step thus switching off the catalysis, while an acid stimulus reversed the action to switch on the reaction again.

Tetrabutylammonium Bromide-Catalyzed Transfer Hydrogenation of Quinoxaline with HBpin as a Hydrogen Source

A metal-free environmentally benign, simple, and efficient transfer hydrogenation process of quinoxaline has been developed using the HBpin reagent as a hydrogen source. This reaction is compatible with a variety of quinoxalines offering the desired tetrahydroquinoxalines in moderate-to-excellent yields with Bu4NBr as a noncorrosive and low-cost catalyst.

NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy

A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.

Utilization of renewable formic acid from lignocellulosic biomass for the selective hydrogenation and/or N-methylation

Lignocellulosic biomass is one of the most abundant renewable sources in nature. Herein, we have developed the utilization of renewable formic acid from lignocellulosic biomass as a hydrogen source and a carbon source for the selective hydrogenation and further N-methylation of various quinolines and the derivatives, various indoles under mild conditions in high efficiencies. N-methylation of various anilines is also developed. Mechanistic studies indicate that the hydrogenation occurs via a transfer hydrogenation pathway.

A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors

Ferroptosis is a recently characterized form of regulated necrosis with the iron-dependent accumulation of (phospho)lipid hydroperoxides (LOOH). It has attracted considerable attention for its putative involvement in diverse pathophysiological processes, such as cardiovascular disease and neurodegeneration. Here we describe the discovery of tetrahydroquinoxaline, a novel scaffold of ferroptosis inhibitors based on quantum chemistry methods. Tetrahydroquinoxaline deviates showed very good inhibition of ferroptosis, while being non cytotoxic for human cancer cells. And, the advantage of them is their small molecular weight (MW. = 148 Da) that can be coupled with other drugs to form multi-target drugs to better meet the treatment of complicated diseases.

Tetrahydroquinoxaline compound, and preparation method and application thereof

The invention provides a tetrahydroquinoxaline compound, and a preparation method and application thereof. The chemical structure is shown in a formula I: the tetrahydroquinoxaline compound has good cell ferroptosis inhibition activity, and can be used fo

Transfer hydrogenation of nitrogen heterocycles using a recyclable rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica

Transfer hydrogenation of unsaturated nitrogen heterocycles using a rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica (BPy-PMO) is described. The immobilized catalyst was prepared by mixing [Cp?RhCl2]2 (Cp?