133120-37-3

Basic information

• Product Name: 5-oxo(4-nitrobenzoyl)-23-oxonemadectin
• Synonyms: 5-oxo(4-nitrobenzoyl)-23-oxonemadectin
• CAS NO: 133120-37-3
• Molecular Weight: 759.894
• Mol File: 133120-37-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-oxo(4-nitrobenzoyl)-23-oxonemadectin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo(4-nitrobenzoyl)-23-oxonemadectin(133120-37-3)
• EPA Substance Registry System: 5-oxo(4-nitrobenzoyl)-23-oxonemadectin(133120-37-3)

Safety Data

• Hazardous Substances Data: 133120-37-3(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 102130-84-7 nemadectin α 

Relevant articles and documents

Method for synthesizing moxidectin

The invention provides a method for synthesizing moxidectin. The method comprises the following steps of: 1) adding a protective substance into nemadectin M0 to react, and protecting 3'-hydroxyl of the nemadectin M0 to obtain an upper protective intermediate M1; 2) oxidizing the upper protective intermediate M1 by using a Dess-Martin periodinane to obtain an oxidized intermediate M2; 3) carrying out deprotection on the oxidized intermediate M2 to obtain a deprotected intermediate M3; and 4) carrying out oximation reaction on the deprotected intermediate M3 to obtain moxidectin MX. According tothe method, the Dess-Martin periodinane is used for replacing a Swern oxidation system and PCC/PDC oxidation in the prior art to oxidize the upper protective intermediate M1 to prepare the moxidectinkey intermediate M2, the oxidation condition is mild, the method can be carried out at normal temperature, and low temperature is not needed; moreover, the oxidation reaction is good in selectivity and high in yield, and the obtained oxidation intermediate M2 is high in purity.

Selective oxidation process with enhanced safety

A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(C2-C4 alkanoyloxy-1,1 -dihydro-1,2-benziodoxol-3(1H)-one, and a composition useful in this process.