133130-13-9

Usage

Chemical compound

A substance with a specific chemical structure and properties.

Also known as

Isobutyroquinone.

Derivative of

1,2-naphthoquinone.

Found in

Various plant sources.

Studied for

Potential antioxidant and anti-inflammatory properties.

Investigated for

Potential use in the treatment of inflammatory and oxidative stress-related conditions.

Potential as

A food additive and preservative.

Therapeutic benefits

May reduce inflammation and oxidative stress in various diseases.

Further research needed

To fully understand its effects and potential uses.
It's worth noting that this is a summary of the main properties and specific content of isobutyroquinone based on the material provided, and further research and study would be needed to fully understand its properties and potential uses.

Upstream product

• 60683-46-7 3-isopropylnaphthalen-2-ol 
• 100883-22-5 3-isopropyl-2-methoxynaphthalene 
• 100971-64-0 7-methoxy-6-isopropyl-1,2-dihydronaphthalene 
• 133130-12-8 6-Isopropyl-7-methoxy-1,2,3,4-tetrahydro-[1]naphthol 
• 22009-41-2 6-isopropyl-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 
• 7467-75-6 2-hydroxy-3-isopropylnaphthalene-1,4-dione 

Relevant academic research and scientific papers

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.

Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza bunge (Danshen)

Twenty one o-quinonoid-type compounds and one coumarin-type compound related to miltirone (1) have been synthesized with the aim to identify the key structural elements involved in miltirone's interaction with the central benzodiazepine receptor. On the basis of their inhibition of [3H]flunitrazepam binding to bovine cerebral cortex membranes, it is apparent that ring A of miltirone is essential for affinity. Although increasing the size of ring A from six-membered to seven- and eight-membered is well-tolerated, the introduction of polar hydroxyl groups greatly reduces binding affinity. The presence of 1,1-dimethyl groups on ring A is, however, not essential. On the other hand, the isopropyl group on ring C appears to be critical for binding as its removal decreases affinity by more than 30-fold. It can, however, be replaced with a methyl group with minimal reduction in affinity. Finally, linking ring A and B with a -CH2CH2- bridge results in analogue 89, which is 6 times more potent than miltirone at the central benzodiazepine receptor (IC50 = 0.05 μM).