7467-75-6

Basic information

• Product Name: 4-hydroxy-3-(propan-2-yl)naphthalene-1,2-dione
• CAS NO: 7467-75-6
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.2326
• Mol File: 7467-75-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 366.5°C at 760 mmHg
• Flash Point: 189.6°C
• Density: 1.289g/cm³
• Vapor Pressure: 5.13E-06mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 4-hydroxy-3-(propan-2-yl)naphthalene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-(propan-2-yl)naphthalene-1,2-dione(7467-75-6)
• EPA Substance Registry System: 4-hydroxy-3-(propan-2-yl)naphthalene-1,2-dione(7467-75-6)

Safety Data

• Hazardous Substances Data: 7467-75-6(Hazardous Substances Data)

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 3437-84-1 isobutyroyl peroxide 
• 1539-32-8 4-isopropyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 130-15-4 [1,4]naphthoquinone 
• 1785-67-7 1,2,4-triacetyloxynaphthalene 

Downstream Products

• 528-46-1 phthalonic acid 
• 79-31-2 isobutyric Acid 
• 133130-13-9 3-isopropyl-[1,2]naphthoquinone 

Relevant articles and documents

Visible-light-mediated minisci C-H alkylation of heteroarenes with 4-alkyl-1,4-dihydropyridines using O2as an oxidant

Herein, we report a protocol for direct visible-light-mediated Minisci C-H alkylation reactions of N-heteroarenes with 4-alkyl-1,4-dihydropyridines at room temperature with molecular oxygen as an oxidant. The protocol permits efficient functionalization of various N-heteroarenes with a broad range of cyclic and acyclic primary, secondary, and tertiary alkyl groups and is scalable to the gram level. This mild protocol uses an inexpensive, green oxidant and is suitable for late-stage C-H alkylation of complex nitrogen-containing molecules. We demonstrated its utility by preparing or functionalizing several pharmaceuticals and natural products.