133131-18-7Relevant academic research and scientific papers
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome
Baugh, Simon D.P.,Pabba, Praveen K.,Barbosa, Joseph,Coulter, Eric,Desai, Urvi,Gay, Jason P.,Gopinathan, Suma,Han, Qiang,Hari, Rajee,Kimball, S. David,Nguyen, Huy V.,Ni, Chi-You,Powell, David R.,Smith, Arian,Terranova, Kristen M.,Wilson, Alan,Yu, Xuan-Chuan,Lombardo, Victoria K.
, p. 3836 - 3839 (2015/08/24)
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole
