133161-14-5

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 133161-13-4 (S)-N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine 

Downstream Products

• 144604-92-2 (2S,3S,4R)-3,4-Dihydroxy-2-(4-trityloxy-butyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 144604-90-0 (2S,3S)-3-Hydroxy-2-(4-trityloxy-butyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 144604-91-1 (S)-2-(4-Trityloxy-butyl)-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester 
• 144604-94-4 (3aS,4S,6aR)-4-(4-Methanesulfonyloxy-butyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 
• 144604-93-3 (3aS,4S,6aR)-4-(4-Hydroxy-butyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of 1-hydroxyindolizidines, biosynthetic precursors to the toxic indolizidine alkaloids slaframine and swainsonine

An enantioselective synthesis of 1-hydroxyindolizidines (1 and 2) from racemic N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine (3) by following the Sharpless kinetic resolution, intramolecular amidomercuration, and radical Michael addition as key steps is d

ELECTROPHILIC OLEFIN HETEROCYCLIZATION IN ORGANIC SYNTHESIS. STEREOSELECTIVE INTRAMOLECULAR AMIDOMERCURATION OF γ-HYDROXY-δ,ε-UNSATURATED URETHANES

Mercuric acetate driven cyclization of γ-hydroxy-δ,ε-unsaturated urethanes 1a,b proceeded regio- and stereoselectively to afford cis-2-acetoxymercurymethyl-3-hydroxypyrrolidines 2a,b, respectively.These were transformed into the key intermediates for seve