1331753-63-9

Upstream product

• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 95-54-5 1,2-diamino-benzene 
• 1829-28-3 ethyl 2-iodobenzoate 
• 87-25-2 2-ethoxycarbonylaniline 
• 23868-21-5 ethyl 2-((2-chlorophenyl)amino)benzoate 
• 694-80-4 2-bromo-1-chlorobenzene 

Downstream Products

• 5814-41-5 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one 
• 32047-69-1 10-methyl-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one 

Relevant academic research and scientific papers

RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USAGE THEREOF

The present invention discloses a receptor inhibitor of formula (I), a composition comprising the same and the usage thereof.

Transition-metal-free tandem oxidative removal of benzylic methylene group by C-C and C-N bond cleavage followed by intramolecular new aryl C-N bond formation under radical conditions

A novel tandem oxidative conversion of 10,11-dihydro-5H-dibenzo[b,e][1,4]diazepines to phenazines has been achieved under transition-metal-free, mild conditions using K2S2O8 or DDQ as the oxidizing agent. The transformation proceeds through oxidative removal of a benzylic methylene group by C-C and C-N bond cleavage followed by a new aryl C-N bond formation under radical conditions.

Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.