133181-64-3

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-Isopropylpiperazine is used as an active pharmaceutical ingredient for its antihypertensive, anti-inflammatory, and antifungal properties, contributing to the development of medications that address a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, (2S)-Isopropylpiperazine is utilized as a component in the formulation of products designed to protect crops from various fungal infections, thereby enhancing agricultural productivity.
Used as a Chemical Intermediate:
(2S)-Isopropylpiperazine serves as a crucial intermediate in the synthesis of a variety of organic compounds, facilitating the creation of new chemical entities with potential applications across different industries.
Used in Psychoactive Substance Research:
Due to its effects on the central nervous system, (2S)-Isopropylpiperazine is employed in research aimed at understanding and developing substances that can influence cognitive and emotional processes, which may have implications for the treatment of neurological and psychiatric disorders.

InChI:InChI=1/C7H16N2/c1-6(2)7-5-8-3-4-9-7/h6-9H,3-5H2,1-2H3

Upstream product

• 16944-60-8 (2S)-isopropylpiperazine-3,6-dione 
• 674792-05-3 (S)-tert-butyl 2-isopropylpiperazine-1-carboxylate 
• 324748-62-1 (S)-1-benzyl-3-isopropylpiperazine 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 2421-61-6 N-benzyloxycarbonylvalylglycine methyl ester 

Downstream Products

• 133181-65-4 (S)-1,4-di-(benzyloxycarbonyl)-2-isopropylpiperazine 
• 502493-89-2 C₂₀H₂₆N₂ 

Relevant academic research and scientific papers

KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma

The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induced mouse model of ocular hypertension, the compounds reduce intraocular pressure to baseline levels. The compounds also increase outflow facility in a pig eye perfusion assay. These results suggest LIMK2 may be an effective target for treating ocular hypertension and associated glaucoma.

NOVEL COMPOUNDS

There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES

In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17?-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of

17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases

In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of

17-Beta hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases

There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

Piperazine derivative

A piperazine compound represented by formula (1): wherein X is —CH2—, —C(O)— or —CH(CH3)—; R1is a hydrogen atom or alkyl group; and R2is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

CHIRAL LIGANDS CONTAINING HETEROATOMS. V ENANTIOSELECTIVE KETONE REDUCTION USING CHIRAL DIAMINES/METAL HYDRIDE SYSTEMS

New chiral reducing agents prepared from zinc or magnesium dichloride, optically active diamines and diisobutylaluminium hydride, have been studied.These complexes were used in the reduction of a series of prochiral ketones and, compared with similar tin(