133217-40-0Relevant academic research and scientific papers
Acyloxymethyl carbonochloridates. New intermediates in prodrug synthesis
Folkmann,Lund
, p. 1159 - 1166 (1990)
The synthesis of a number of stable acyloxymethyl carbonochloridates 7 has been accomplished in four steps from chloromethyl carbonochloridate 3. Each step has been optimized with propanoyl-oxymethyl carbonochloridate 7c as a model compound (64% overall yield). Diethyl ether-boron trifluoride catalyzes the conversion of carbonothioate 6cc to the carbonochloridate 7c by chlorination with sulfuryl chloride. Acylation of a few compounds containing hydroxy or amino groups by 7c is described.
Cell permeable inhibitors of anaphase promoting complex
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Page/Page column 38; 39, (2017/03/14)
The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting com
