Cas 1332258-89-5,N-benzoylmatrinic acid

1332258-89-5

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Basic information

Product Name: N-benzoylmatrinic acid
Synonyms: N-benzoylmatrinic acid
CAS NO:1332258-89-5
Molecular Formula:
Molecular Weight: 370.492
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N-benzoylmatrinic acid(CAS DataBase Reference)
NIST Chemistry Reference: N-benzoylmatrinic acid(1332258-89-5)
EPA Substance Registry System: N-benzoylmatrinic acid(1332258-89-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1332258-89-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1332258-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,2,2,5 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1332258-89:
(9*1)+(8*3)+(7*3)+(6*2)+(5*2)+(4*5)+(3*8)+(2*8)+(1*9)=145
145 % 10 = 5
So 1332258-89-5 is a valid CAS Registry Number.

1332258-89-5Upstream product

1332258-89-5Downstream Products

1332258-89-5Relevant academic research and scientific papers

MATRINIC ACID/ MATRINE DERIVATIVES AND PREPARATION METHODS AND USES THEREOF

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Paragraph 0098, (2013/04/25)

The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/orAIDS.

Synthesis, structure-activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators

Du, Na-Na,Li, Xin,Wang, Yu-Ping,Liu, Fei,Liu, Yan-Xin,Li, Chun-Xin,Peng, Zong-Gen,Gao, Li-Mei,Jiang, Jian-Dong,Song, Dan-Qing

, p. 4732 - 4735 (2011/09/16)

Oxymatrine (1) is a natural anti-hepatitis B virus (HBV) drug that down-regulates host heat-stress cognate 70 (Hsc70) expression through a mechanism different from that of nucleosides. Taking Hsc70 as a target against HBV, 26 novel N-substituted matrinic acid analogs were designed, synthesized and evaluated for their regulation of Hsc70 mRNA expression with 1 as the lead. The SAR analysis revealed that (i) the carboxyl group at the 11-position was required for activity; (ii) introducing of a substituent on the nitrogen atom at the 12-position of 3, especially substituted benzyl, might significantly improve the activity. Among these analogs, compound 9p possessing N-p-methoxylbenzyl afforded an increased anti-HBV effect in comparison with 1. We consider 9p a promising anti-HBV candidate.

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