13324-82-8Relevant academic research and scientific papers
One-pot B(C6F5)3 catalyzed cascade synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones
Shinde, Achut R.,Mane, Yogesh D.,Muley, Dnyanoba B.
supporting information, p. 33 - 40 (2019/11/19)
A new and efficient B(C6F5)3 catalyzed domino strategy has been developed for the synthesis of 2-substituted quinazolinones. The reaction utilizes 2-aminobenzamide and aldehydes for a one-pot protocol. A wide range of substrate scope, functional group tolerance, and operational simplicity with excellent yield are synthetically useful features.
KOH/DMSO: A basic suspension for transition metal-free Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Dutta, Apurba,Damarla, Krishnaiah,Bordoloi, Ankur,Kumar, Arvind,Sarma, Diganta
supporting information, p. 1614 - 1619 (2019/05/24)
A novel protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzamides and aldehyde derivatives catalyzed by KOH/DMSO suspension has been developed. The present transition metal free methodology is operationally simple, scalable and varieties of 2,3-dihydroquinazolin-4(1H)-one derivatives were obtained in good to excellent yields in short reaction times.
Efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-ones promoted by FeCl3/neutral Al2O3
Wu, Suo Juan,Zhao, Zi Qiang,Gao, Jing Shuo,Chen, Bao Hua,Chen, Guo Feng
, p. 2327 - 2339 (2019/02/01)
2,3-Dihydroquinazolin-4(1H)-one derivatives have been synthesized via one-pot reaction of isatoic anhydride, aromatic aldehyde, and ammonium acetate catalyzed by FeCl3/neutral Al2O3 in tert-butanol under reflux conditions.
A concise aqueous phase supramolecular synthesis of 2-phenyl-2,3- dihydroquinazolin-4(1H)-one derivatives
Ramesh,Karnakar,Satish,Anil Kumar,Nageswar
supporting information, p. 6936 - 6939 (2013/01/15)
2-Phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized for the first time in water under neutral conditions by the reaction of aldehyde, and anthranilamide mediated by β-cyclodextrin in high yields. β-Cyclodextrin can be recovered and reused with a small loss of catalytic activity.
Tandem supramolecular synthesis of substituted 2-aryl-2,3- dihydroquinazolin-4(1H)-ones in the presence of β-cyclodextrin in water
Ramesh,Karnakar,Satish,Harsha Vardhan Reddy,Nageswar
supporting information, p. 6095 - 6099 (2012/11/07)
Substituted 2-aryl-2,3-dihydroquinazolin-4(1H)-ones were prepared for the first time in water under neutral conditions by the reaction of aniline, isatoic anhydride, and aldehyde mediated by β-cyclodextrin in good yields. β-Cyclodextrin can be recovered a
New conditions for synthesis of (plusmn;)-2-monosubstituted and (plusmn;)-2,2-disubstituted 2,3-dihydro-4(1H)-quinazolinones from 2-nitro- and 2-aminobenzamide
Bunce, Richard A.,Nammalwar, Baskar
experimental part, p. 991 - 997 (2011/11/06)
An efficient synthesis of (plusmn;)-2-monosubstituted and (plusmn;)-2,2-disubstituted 2,3-dihydro-4(1H)-quinazolinones has been developed using a dissolving metal reduction-condensative cyclization strategy. Treatment of 2-nitrobenzamide and an aldehyde or ketone with iron powder in refluxing acetic acid affords high yields of the title compounds. More complex ring systems are available by incorporating additional reactive functionality γ to the carbonyl of the aldehyde or ketone substrate. The scope and limitations of the process along with optimized procedural details are presented. The same target molecules are also accessible by reaction of 2-aminobenzamide with aldehydes and ketones in refluxing acetic acid.
