610-15-1

Basic information

• Product Name: 2-NITROBENZAMIDE
• Synonyms: 2-nitro-benzamid;2-Nitrobenzoesαureamid;Benzamide, o-nitro-;Benzamide,2-nitro-;Benzmide, 2-nitro-;o-nitro-benzamid;2-Nitrobenzamide,98%;NSC 407995
• CAS NO: 610-15-1
• Molecular Formula: C₇H₆N₂O₃
• Molecular Weight: 166.13
• EINECS: 210-208-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 610-15-1.mol
• Article Data: 64

Chemical Properties

• Melting Point: 174-178 °C(lit.)
• Boiling Point: 317 °C(lit.)
• Flash Point: 317°C
• Appearance: /
• Density: 1.384
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5880 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.09±0.50(Predicted)
• BRN: 1950928
• CAS DataBase Reference: 2-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITROBENZAMIDE(610-15-1)
• EPA Substance Registry System: 2-NITROBENZAMIDE(610-15-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: CV5600000
• Hazardous Substances Data: 610-15-1(Hazardous Substances Data)

Usage

Chemical Properties

beige crystalline powder

Uses

2-Nitrobenzamide was used in the synthesis of novel fluorogenic chemosensors based on urea derivative of 2-(2′-aminophenyl)-4-phenylthiazole. It was also used in the synthesis of quinazoline-2,4(1H,3H)-diones, an important class of pharmaceutical intermediates.

General Description

Water solubility - <0.1 mg/mL at 64°F.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for 2-NITROBENZAMIDE are not available, however 2-NITROBENZAMIDE is probably combustible.

InChI:InChI=1/C7H6N2O3/c8-7(10)5-3-1-2-4-6(5)9(11)12/h1-4H,(H2,8,10)

Upstream product

• 110-86-1 pyridine 
• 552-16-9 ortho-nitrobenzoic acid 
• 5994-87-6 diphenylphosphinamide 
• 6635-41-2 (Z)-2-nitrobenzaldehyde oxime 
• 4836-00-4 (E)-2-nitrobenzaldehyde oxime 
• 77287-34-4 formamide 
• 612-24-8 o-nitrobenzonitrile 
• 610-14-0 2-nitrobenzyl chloride 
• 110822-03-2 N-(2-nitrobenzoyl)thiazolidine-4-carboxylic acid 
• 78188-01-9 2-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyloxy)-2-<3-(2'-nitrobenzoyloxy)phenyl>acetonitril 
• 55-21-0 benzamide 
• 113780-54-4 N-(2-pyridylthio)-o-nitrobenzamid 
• 33348-83-3 2-nitro-benzoic acid bromoamide 
• 141-52-6 sodium ethanolate 

Downstream Products

• 99595-86-5 2-nitro-N-(hydroxymethyl)benzamide 
• 345931-29-5 (1,3-Dihydroxy-1,3-dihydro-isoindol-2-yl)-(2-nitro-phenyl)-methanone 
• 79388-59-3 Dimethyl N-(2-nitrobenzoyl)-carbonimidodithioate 
• 950-31-2 1H-spiro(cyclohexane-1,2-quinazolin)-4(3H)-one 
• 81038-76-8 2,2-diethyl-1,2,3,4-tetrahydroquinazolin-4-one 
• 55695-67-5 N-(2-Carbamoyl-phenyl)-3,4,5-trimethoxy-benzamide 
• 111986-20-0 N-((4-((5-bromopyrimidin-2-yl)oxy)-3-methylphenyl)carbamoyl)-2-nitrobenzamide 
• 1024606-11-8 trans-N-hex-1-enyl-2-nitro-benzamide 
• 70102-35-1 2-nitrobenzothioamide 
• 13906-05-3 3-benzyl-2-thioxo-1,2-dihydro-4(3H)-quinazolinone 
• 13906-07-5 3-butyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 1234324-34-5 C₂₀H₂₂N₂O₃ 
• 1234324-12-9 C₁₈H₂₀N₂O₂ 
• 1019325-31-5 C₁₄H₈ClFN₂ 

Relevant articles and documents

METHODS OF CONTROLLING CROP PESTS USING AROMATIC AMIDE INSECT REPELLENTS, METHODS OF MAKING AROMATIC AMIDE INSECT REPELLENTS, AND NOVEL AROMATIC AMIDE INSECT REPELLENTS

Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal. The compounds have the formula RxC6Hy—C(═O)—N(Cy), where RxC6Hy is a substituted phenyl group, each R group is independently C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, C1-C4 alkoxy, C6-C10 aryloxy, halogen, nitro, cyano, cyanate, isocyanate, nitroso, C1-C4 alkylthio, phenylthio, (halogen-substituted) C1-C4 alkylsulfonyl, phenylsulfonyl, tolylsulfonyl, amino, mono- or di-C1-C4 alkylamino, diphenylamino, di-C1-C4 alkylamido, formyl, C2-C7 acyl, or C1-C6 alkoxycarbonyl; x is an integer of 1 to 5; x+y=5; Cy is a C2-C8 (substituted) alkadiyl, a C4-C6 (substituted) alkenediyl, or a (substituted) diyl of the formula —(CH2CH2)—O—(CH2CH2)—, —(CH2CH2)—NR′—(CH2CH2)— or —(CH2CH2)—S—(CH2CH2)— that, along with the amide N atom, forms a non-aromatic cyclic group; and R′ is C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, or (substituted) benzyl.

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions

Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols. This journal is