1332525-29-7Relevant academic research and scientific papers
Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: Use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group
ElMarrouni, Abdellatif,Heras, Montserrat
, p. 851 - 858 (2014)
The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic substitution reaction between 4-[4-(benzyloxy)benzylo
Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts
Elmarrouni, Abdelatif,Fabrellas, Josep M.,Heras, Montserrat
experimental part, p. 5967 - 5977 (2011/10/09)
Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.
